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Projects
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Distinct functions for CD8 T cells in cutaneous leishmaniasis
Novais, F. (PI)
National Institute of Allergy and Infectious Diseases
02/7/22 → 01/31/26
Project: Research
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The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Jin, J., Zhang, R., Li, J., Gao, F., Liao, Z., Yu, Y., Wang, Y., Bucci, D., Xiao, M., Ma, R., Ma, Q., Gao, S., Lio, J., Novais, F., Huang, S. C. C., Zhu, J., Ghoneim, H., Wen, H., Li, Z. & Sun, N. & 1 others, , Mar 11 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 10, e2424061122.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
CCR5 promotes the migration of pathological CD8+ T cells to the leishmanial lesions
Sacramento, L. A., Amorim, C. F., Lombana, C. G., Beiting, D., Novais, F., Carvalho, L. P., Carvalho, E. M. & Scott, P., May 2024, In: PLoS pathogens. 20, 5 May, e1012211.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Neutrophil-mediated hypoxia drives pathogenic CD8+ T cell responses in cutaneous leishmaniasis
Fowler, E. A., Amorim, C. F., Mostacada, K., Yan, A., Sacramento, L. A., Stanco, R. A., Hales, E. D. S., Varkey, A., Zong, W., Wu, G. D., de Oliveira, C. I., Collins, P. L. & Novais, F. O., Jul 15 2024, In: Journal of Clinical Investigation. 134, 14, e177992.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Multiomic profiling of cutaneous leishmaniasis infections reveals microbiota-driven mechanisms underlying disease severity
Amorim, C. F., Lovins, V. M., Singh, T. P., Novais, F. O., Harris, J. C., Lago, A. S., Carvalho, L. P., Carvalho, E. M., Beiting, D. P., Scott, P. & Grice, E. A., Oct 18 2023, In: Science Translational Medicine. 15, 718, eadh1469.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
NKG2D promotes CD8 T cell-mediated cytotoxicity and is associated with treatment failure in human cutaneous leishmaniasis
Sacramento, L. A., Amorim, C. F., Campos, T. M., Saldanha, M., Arruda, S., Carvalho, L. P., Beiting, D. P., Carvalho, E. M., Novais, F. O. & Scott, P., Aug 2023, In: PLoS Neglected Tropical Diseases. 17, 8, e0011552.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations