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Collaborations and top research areas from the last five years
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Essential functions of OGT in host defense mechanism
Wen, H. (PI)
National Institute of General Medical Sciences
09/5/24 → 06/30/26
Project: Research
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Targeting immune inhibitory molecule SUSD2 to reverse immunosuppression
Wen, H. (PI)
National Institute of Allergy and Infectious Diseases
06/17/21 → 05/31/26
Project: Research
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Mitochondrial metabolism in microbial sepsis
Wen, H. (PI)
National Institute of General Medical Sciences
09/15/19 → 07/31/23
Project: Research
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Nebraska Center for Molecular Target Discovery and Development
Lewis, R. E. (PI), Black, A. R. (CoPI), Alvarez, S. (CoPI), Natarajan, A. (CoPI), Buckley, S. (CoPI), Conda Sheridan, M. M. (CoPI), Ghosal, G. (CoPI), Mathew, G. G. (CoPI), Hewitt, K. J. (CoPI), Yoo, J. J. H. (CoPI), Kelly, D. L. (CoPI), Fisher, K. (CoPI), Luo, X. (CoPI), Schott, M. M. (CoPI), Ramanathan, S. S. P. (CoPI), Choi, S. S. (CoPI), Wang, J. (CoPI), Wen, H. (CoPI) & Woods, N. (CoPI)
03/16/18 → 06/30/24
Project: Research
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Immunometabolism in microbial sepsis
National Institute of General Medical Sciences
08/15/17 → 06/30/22
Project: Research
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O-GlcNAc transferase plays dual antiviral roles by integrating innate immunity and lipid metabolism
Dong, H., Liang, C., Zhang, J., Wu, W., Kumar, N., Liu, Z., Sun, Y., Liao, Z., Cheng, X., Yu, Y., Zhang, Y., Holtzman, M. J., Li, J., Gowdy, K. M., Thomas, P. G., Badjic, J. D., Ma, A., Ma, Q., Yount, J. S. & Liu, S. L. & 1 others, , Dec 2025, In: Nature Communications. 16, 1, 7721.Research output: Contribution to journal › Article › peer-review
Open Access7 Link opens in a new tab Scopus citations -
Proteotoxic stress response drives T cell exhaustion and immune evasion
Wang, Y., Ma, A., Song, N. J., Shannon, A. E., Amankwah, Y. S., Chen, X., Wu, W., Wang, Z., Saadey, A. A., Yousif, A., Ghosh, G., Mandula, J. K., Velegraki, M., Xiao, T., Wen, H., Huang, S. C. C., Wang, R., Beusch, C. M., Dawood, A. S. & Gordon, D. E. & 5 others, , Nov 27 2025, In: Nature. 647, 8091, p. 1025-1035 11 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Link opens in a new tab Scopus citations -
RETRACTED ARTICLE: Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy (Nature Microbiology, (2021), 6, 3, (366-379), 10.1038/s41564-020-00843-2)
Li, T., Kong, L., Li, X., Wu, S., Attri, K. S., Li, Y., Gong, W., Zhao, B., Li, L., Herring, L. E., Asara, J. M., Xu, L., Luo, X., Lei, Y. L., Ma, Q., Seveau, S., Gunn, J. S., Cheng, X., Singh, P. K. & Green, D. R. & 2 others, , Sep 2025, In: Nature Microbiology. 10, 9, p. 2354 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Jin, J., Zhang, R., Li, J., Gao, F., Liao, Z., Yu, Y., Wang, Y., Bucci, D., Xiao, M., Ma, R., Ma, Q., Gao, S., Lio, J., Novais, F., Huang, S. C. C., Zhu, J., Ghoneim, H., Wen, H., Li, Z. & Sun, N. & 1 others, , Mar 11 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 10, e2424061122.Research output: Contribution to journal › Article › peer-review
Open Access6 Link opens in a new tab Scopus citations -
USP30 inhibition augments mitophagy to prevent T cell exhaustion
Zhang, R., Gao, F., Li, J., Jin, J., Chen, K., Chaudhuri, S., Liao, Z., Xiao, T., Xu, Y., Wen, H., He, K., Li, Z., Xin, G. & Sun, N., Aug 2025, In: Science Advances. 11, 33, eadv6902.Research output: Contribution to journal › Article › peer-review
Open Access5 Link opens in a new tab Scopus citations