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Chemoenzymatic Protein Semisynthesis Approaches Toward Cell Signaling Enzymes
Chu, N. (PI)
National Institute of General Medical Sciences
09/1/23 → 08/31/26
Project: Research
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Structural and mechanistic basis of mTORC2 activation of protein kinase AKT/PKB
Chu, N., Le, N., Nebie, O. & Yang, S., Feb 2026, In: Biochemical Journal. 483, 3, p. 375-389 15 p.Research output: Contribution to journal › Review article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2
Taylor, M. S., Chen, M., Hancock, M., Wranik, M., Miller, B. D., O’Meara, T. R., Palanski, B. A., Ficarro, S. B., Groendyke, B. J., Xiang, Y., Kondo, K. T., Linde-Garelli, K. Y., Lee, M. J., Mondal, D., Freund, D., Congreve, S., Matas, K., Hennink, M., Xibinaku, K. & Valenstein, M. L. & 9 others, , Mar 5 2026, In: Science. 391, 6789, eadv7111.Research output: Contribution to journal › Article › peer-review
Open Access8 Link opens in a new tab Scopus citations -
Prion protein pathology in Ubiquilin 2 models of ALS
Le, N. T., Chu, N., Joshi, G., Higgins, N. R., Nebie, O., Adelakun, N., Butts, M. & Monteiro, M. J., Oct 15 2024, In: Neurobiology of Disease. 201, 106674.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations -
Analyzing protein posttranslational modifications using enzyme-catalyzed expressed protein ligation
Adelakun, N., Parrish, J. & Chu, N., Jan 2023, Integrated Methods in Protein Biochemistry: Part C. Shukla, A. K. (ed.). Academic Press Inc., p. 319-350 32 p. (Methods in Enzymology; vol. 682).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Multifaceted Regulation of Akt by Diverse C-Terminal Post-translational Modifications
Salguero, A. L., Chen, M., Balana, A. T., Chu, N., Jiang, H., Palanski, B. A., Bae, H., Wright, K. M., Nathan, S., Zhu, H., Gabelli, S. B., Pratt, M. R. & Cole, P. A., Jan 21 2022, In: ACS Chemical Biology. 17, 1, p. 68-76 9 p.Research output: Contribution to journal › Article › peer-review
21 Link opens in a new tab Scopus citations