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Dive into the research topics where Nicholas Charles Denko is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Collaborations and top research areas from the last five years
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Overcoming Hypoxic Resistance in Non-Small Cell Lung Cancer By Targeting Mitochondrial Metabolism
Denko, N. C. (PI), Williams, T. M. (CoPI) & Li, Z. Z. (CoPI)
09/22/21 → 08/31/26
Project: Research
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Overcoming hypoxic resistance to anti-cancer therapy
Denko, N. C. (PI) & Li, Z. Z. (CoPI)
12/15/20 → 11/30/25
Project: Research
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A phase 0 pilot study to determine if papaverine increases oxygenation in spontaneous canine soft tissue sarcoma
Denko, N. C. (PI)
08/1/19 → 01/31/22
Project: Research
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SARRP 200 Small animal radiation research platform
Denko, N. C. (PI)
03/23/15 → 03/22/16
Project: Research
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Decreasing hypoxia with mitochondrial inhibition in locally advanced rectal cancer: Phase 1 trial of papaverine in combination with radiation (DINOMITE).
Miller, E. D., Kasi, P. M., Li, J., Denko, N., Weng, J., Pitter, K., Kalady, M., Liu, Y., McGee, H. M., Fakih, M., Kaiser, A. & Williams, T. M., Jan 2026, In: Journal of Clinical Oncology. 44, p. TPS274-TPS274Research output: Contribution to journal › Review article › peer-review
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Development of Selective and Soluble Mitochondrial Complex 1 Inhibitors Derived from Papaverine for Radiosensitization of Cancer
Haines, B. J., Kreamer, M., Benej, M., Mohammed, S., Bridge, H., Bayrali-Ulker, E., Fergatova, A., Williams, T. M., Li, Z., Papandreou, I., Denko, N. C. & Mitton-Fry, M. J., Nov 13 2025, In: Journal of Medicinal Chemistry. 68, 21, p. 23140-23162 23 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Link opens in a new tab Scopus citations -
Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Jin, N., Hoyd, R., Yilmaz, A. S., Zhu, J., Liu, Y., Jagjit Singh, M. S., Grencewicz, D. J., Mo, X., Kalady, M. F., Rosenberg, D. W., Dravillas, C. E., Singer, E. A., Carpten, J. D., Chan, C. H. F., Churchman, M. L., Denko, N., Clemente, F. D., Dodd, R. D., Eljilany, I. & Fei, N. & 16 others, , Jan 2025, In: Cancer research communications. 5, 11, p. 1985-1997 13 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Link opens in a new tab Scopus citations -
Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation
Estephan, H., Tailor, A., Parker, R., Kreamer, M., Papandreou, I., Campo, L., Easton, A., Moon, E. J., Denko, N. C., Ternette, N., Hammond, E. M. & Giaccia, A. J., Feb 3 2025, In: EMBO Journal. 44, 3, p. 903-922 20 p., 103768.Research output: Contribution to journal › Article › peer-review
Open Access36 Link opens in a new tab Scopus citations -
Hypoxic Gene Expression Signature as a Predictor of Recurrence and Mortality in Early-Stage Non–Small Cell Lung Cancer Treated With Stereotactic Body Radiation Therapy
Eustace, N. J., Sebastian, N. T., Webb, A., Shilo, K., Robb, R., Amini, A., Yang, L., Denko, N. C. & Williams, T. M., Jun 1 2025, In: JCO Precision Oncology. 9, e2400659.Research output: Contribution to journal › Article › peer-review
Open Access1 Link opens in a new tab Scopus citations