A gamma-detecting probe for radioimmune detection of CEA-producing tumors - Successful experimental use and clinical case report

Delmar R. Aitken; George H. Hinkle; Marlin O. Thurston; Steve E. Tuttle; Daniel T. Martin; John Olsen; Darrow E. Haagensen; David Houchens; Edward W. Martin

doi:10.1007/BF02555625

A gamma-detecting probe for radioimmune detection of CEA-producing tumors - Successful experimental use and clinical case report

Delmar R. Aitken
, George H. Hinkle
, Marlin O. Thurston
, Steve E. Tuttle
, Daniel T. Martin
, John Olsen
, Darrow E. Haagensen
, David Houchens
, Edward W. Martin

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.

Original language	English
Pages (from-to)	279-282
Number of pages	4
Journal	Diseases of the Colon & Rectum
Volume	27
Issue number	5
DOIs	https://doi.org/10.1007/BF02555625
State	Published - May 1984

Keywords

CEA
Carcinoembryonic antigen
Gamma-detecting probe
Nuclear medicine tumor scanning
Radioimmune detection
Radiolabeled antibodies

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10.1007/BF02555625

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title = "A gamma-detecting probe for radioimmune detection of CEA-producing tumors - Successful experimental use and clinical case report",

abstract = "The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.",

keywords = "CEA, Carcinoembryonic antigen, Gamma-detecting probe, Nuclear medicine tumor scanning, Radioimmune detection, Radiolabeled antibodies",

author = "Aitken, \{Delmar R.\} and Hinkle, \{George H.\} and Thurston, \{Marlin O.\} and Tuttle, \{Steve E.\} and Martin, \{Daniel T.\} and John Olsen and Haagensen, \{Darrow E.\} and David Houchens and Martin, \{Edward W.\}",

year = "1984",

month = may,

doi = "10.1007/BF02555625",

language = "English",

volume = "27",

pages = "279--282",

journal = "Diseases of the Colon \& Rectum",

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T1 - A gamma-detecting probe for radioimmune detection of CEA-producing tumors - Successful experimental use and clinical case report

AU - Aitken, Delmar R.

AU - Hinkle, George H.

AU - Thurston, Marlin O.

AU - Tuttle, Steve E.

AU - Martin, Daniel T.

AU - Olsen, John

AU - Haagensen, Darrow E.

AU - Houchens, David

AU - Martin, Edward W.

PY - 1984/5

Y1 - 1984/5

N2 - The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.

AB - The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.

KW - CEA

KW - Carcinoembryonic antigen

KW - Gamma-detecting probe

KW - Nuclear medicine tumor scanning

KW - Radioimmune detection

KW - Radiolabeled antibodies

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DO - 10.1007/BF02555625

M3 - Article

C2 - 6714041

AN - SCOPUS:0021320446

SN - 0012-3706

VL - 27

SP - 279

EP - 282

JO - Diseases of the Colon & Rectum

JF - Diseases of the Colon & Rectum

IS - 5

ER -

A gamma-detecting probe for radioimmune detection of CEA-producing tumors - Successful experimental use and clinical case report

Abstract

Keywords

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