A nonsynonymous polymorphism in IRS1 modifies risk of developing breast and ovarian cancers in BRCA1 and ovarian cancer in BRCA2 mutation carriers

Yuan C. Ding, Lesley McGuffog, Sue Healey, Eitan Friedman, Yael Laitman, Shani Paluch Shimon, Bella Kaufman, Annelie Liljegren, Annika Lindblom, Håkan Olsson, Ulf Kristoffersson, Marie Stenmark-Askmalm, Beatrice Melin, Susan M. Domchek, Katherine L. Nathanson, Timothy R. Rebbeck, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna DurdaJacek Gronwald, Tomasz Huzarski, Cezary Cybulski, Tomasz Byrski, Ana Osorio, Teresa Ramóny Cajal, Alexandra V. Stavropoulou, Javier Benítez, Ute Hamann, Matti Rookus, Cora M. Aalfs, Judith L. De Lange, Hanne E.J. Meijers-Heijboer, Jan C. Oosterwijk, Christi J. Van Asperen, Encarna B. Gómez García, Nicoline Hoogerbrugge, Agnes Jager, Rob B. Van Der Luijt, Douglas F. Easton, Susan Peock, Debra Frost, Steve D. Ellis, Radka Platte, Elena Fineberg, D. Gareth Evans, Fiona Lalloo, Louise Izatt, Ros Eeles, Julian Adlard, Rosemarie Davidson, Diana Eccles, Trevor Cole, Jackie Cook, Carole Brewer, Marc Tischkowitz, Andrew K. Godwin, Harsh Pathak, Dominique Stoppa-Lyonnet, Olga M. Sinilnikova, Sylvie Mazoyer, Laure Barjhoux, Mélanie Léoné, Marion Gauthier-Villars, Virginie Caux-Moncoutier, Antoine De Pauw, Agnés Hardouin, Pascaline Berthet, Héléne Dreyfus, Sandra Fert Ferrer, Marie Agnés Collonge-Rame, Johanna Sokolowska, Saundra Buys, Mary Daly, Alex Miron, Mary Beth Terry, Wendy Chung, Esther M. John, Melissa Southey, David Goldgar, Christian F. Singer, Muy Kheng Maria Tea, Daphne Gschwantler-Kaulich, Anneliese Fink-Retter, Thomas V.O. Hansen, Bent Ejlertsen, Oskar T. Johannsson, Kenneth Offi, Kara Sarrel, Mia M. Gaudet, Joseph Vijai, Mark Robson, Marion R. Piedmonte, Lesley Andrews, David Cohn, Leslie R. DeMars, Paul DiSilvestro, Gustavo Rodriguez, Amanda Ewart Toland, Marco Montagna, Simona Agata, Evgeny Imyanitov, Claudine Isaacs, Ramunas Janavicius, Conxi Lazaro, Ignacio Blanco, Susan J. Ramus, Lara Sucheston, Beth Y. Karlan, Jenny Gross, Patricia A. Ganz, Mary S. Beattie, Rita K. Schmutzler, Barbara Wappenschmidt, Alfons Meindl, Norbert Arnold, Dieter Niederacher, Sabine Preisler-Adams, Dorotehea Gadzicki, Raymonda Varon-Mateeva, Helmut Deissler, Andrea Gehrig, Christian Sutter, Karin Kast, Heli Nevanlinna, Kristiina Aittomäki, Jacques Simard, Amanda B. Spurdle, Jonathan Beesley, Xiaoqing Chen, Gail E. Tomlinson, Jeffrey Weitzel, Judy E. Garber, Olufunmilayo I. Olopade, Wendy S. Rubinstein, Nadine Tung, Joanne L. Blum, Steven A. Narod, Sean Brummel, Daniel L. Gillen, Noralane Lindor, Zachary Fredericksen, Vernon S. Pankratz, Fergus J. Couch, Paolo Radice, Paolo Peterlongo, Mark H. Greene, Jennifer T. Loud, Phuong L. Mai, Irene L. Andrulis, Gord Glendon, Hilmi Ozcelik, Anne Marie Gerdes, Mads Thomassen, Uffe Birk Jensen, Anne Bine Skytte, Maria A. Caligo, Andrew Lee, Georgia Chenevix-Trench, Antonis C. Antoniou, Susan L. Neuhausen

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Biochemistry, Genetics and Molecular Biology

Pharmacology, Toxicology and Pharmaceutical Science