A snapshot of challenges and solutions in cancer drug development and therapy

M. A. Phelps; A. Sparreboom

doi:10.1038/clpt.2014.15

A snapshot of challenges and solutions in cancer drug development and therapy

M. A. Phelps, A. Sparreboom

Research output: Contribution to journal › Review article › peer-review

3 Scopus citations

Abstract

Cancer chemotherapy has transitioned from the use of cytotoxic drugs to the era of agents with an apparent selectivity for a cancer-specific target. The past decade has provided evidence that therapy with such agents can be curative in subsets of patients. It is anticipated that incorporation of pharmacological principles for novel therapeutics will result in further refinement of outcome measures as well as the discovery of new treatment modalities for multiple malignant diseases.

Original language	English
Pages (from-to)	341-346
Number of pages	6
Journal	Clinical Pharmacology and Therapeutics
Volume	95
Issue number	4
DOIs	https://doi.org/10.1038/clpt.2014.15
State	Published - Apr 2014

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10.1038/clpt.2014.15

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abstract = "Cancer chemotherapy has transitioned from the use of cytotoxic drugs to the era of agents with an apparent selectivity for a cancer-specific target. The past decade has provided evidence that therapy with such agents can be curative in subsets of patients. It is anticipated that incorporation of pharmacological principles for novel therapeutics will result in further refinement of outcome measures as well as the discovery of new treatment modalities for multiple malignant diseases.",

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AB - Cancer chemotherapy has transitioned from the use of cytotoxic drugs to the era of agents with an apparent selectivity for a cancer-specific target. The past decade has provided evidence that therapy with such agents can be curative in subsets of patients. It is anticipated that incorporation of pharmacological principles for novel therapeutics will result in further refinement of outcome measures as well as the discovery of new treatment modalities for multiple malignant diseases.

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A snapshot of challenges and solutions in cancer drug development and therapy

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