Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice

Fredric B. Weihmuller; Maria Hadjiconstantinou; John P. Bruno

doi:10.1016/0304-3940(88)90443-0

Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice

Fredric B. Weihmuller
, Maria Hadjiconstantinou
, John P. Bruno

Psychiatry

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.

Original language	English
Pages (from-to)	137-142
Number of pages	6
Journal	Neuroscience Letters
Volume	85
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(88)90443-0
State	Published - Feb 15 1988

Keywords

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Behavioral deficit
Haloperidol
Mouse
Parkinsonism
Sensorimotor
Stress

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10.1016/0304-3940(88)90443-0

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title = "Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice",

abstract = "The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.",

keywords = "1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), Behavioral deficit, Haloperidol, Mouse, Parkinsonism, Sensorimotor, Stress",

author = "Weihmuller, \{Fredric B.\} and Maria Hadjiconstantinou and Bruno, \{John P.\}",

note = "Funding Information: This work is supported in part by the American Parkinson's Disease Association and the NINCDS Grant 1 ROI NS23627.",

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AU - Hadjiconstantinou, Maria

AU - Bruno, John P.

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N2 - The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.

AB - The present study evaluates the effects of MPTP-induced striatal DA depletions on sensorimotor behavior in mice. While MPTP produces no obvious behavioral deficits under normal conditions, acute stress (cold swim) or injection of low doses of haloperidol results in marked akinesia, catalepsy, and sensory neglect. Thus, significant behavioral impairments do accompany the neurotoxicity observed after MPTP administration in mice and render this a valuable animal model for studying mechanisms underlying Parkinson's disease.

KW - 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

KW - Behavioral deficit

KW - Haloperidol

KW - Mouse

KW - Parkinsonism

KW - Sensorimotor

KW - Stress

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JO - Neuroscience Letters

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ER -

Acute stress or neuroleptics elicit sensorimotor deficits in MPTP-treated mice

Abstract

Keywords

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