TY - JOUR
T1 - Antigen-directed cancer surgery for primary colorectal cancer
T2 - 15-year survival analysis
AU - Povoski, Stephen P.
AU - Hatzaras, Ioannis S.
AU - Mojzisik, Cathy M.
AU - Arnold, Mark W.
AU - Hinkle, George H.
AU - Hitchcock, Charles L.
AU - Young, Donn C.
AU - Martin, Edward W.
PY - 2012/1
Y1 - 2012/1
N2 - Background: Tumor-associated glycoprotein-72 (TAG-72) is a mucin-like high-molecular-weight glycosylated protein complex overexpressed by many adenocarcinomas. Antigen-directed cancer surgery using radiolabeled anti-TAG-72 murine monoclonal antibodies (muMAbs) has been previously investigated for colorectal cancer. Survival analysis of primary colorectal cancer patients with a minimum of 15-year follow-up after antigen-directed cancer surgery was performed to assess the impact of complete surgical resection of all detectable radiolabeled anti-TAG-72 muMAb. Methods: Survival analysis was performed on 92 patients (study group) with primary colorectal cancer (July 1990 to August 1995) treated with antigen-directed cancer surgery using 125I-labeled anti-TAG-72 muMAb. The study group was subdivided into those with no detectable TAG-72 antigen-bearing tissues (TAG-72 negative, N = 33) and those with persistent detectable TAG-72 antigen-bearing tissues (TAG-72 positive, N = 59) at completion of surgery. Comparisons were made with a control group (546 patients) from the same time period. Results: Study group and control group were demographically similar, as were TAG-72-negative subgroup and TAG-72-positive subgroup. TAG-72-negative subgroup had significantly improved median survival (8.8 versus 2.5 years; P = 0.005) and time-dependent survival (45.4% versus 22.0% at 10 years; P = 0.002 and 39.4% versus 20.3% at 15 years; P = 0.003) compared with TAG-72-positive subgroup. TAG-72 positivity was as an independent predictor of long-term mortality risk, when controlled for pathologic stage of disease. Conclusions: Absence of detectable TAG-72 antigen within the surgical field at completion of antigen-directed cancer surgery for primary colorectal cancer is of significant prognostic value, conferring a long-term survival advantage to those in whom complete surgical removal of all tissues with detectable radiolabeled anti-TAG-72 muMAb was accomplished.
AB - Background: Tumor-associated glycoprotein-72 (TAG-72) is a mucin-like high-molecular-weight glycosylated protein complex overexpressed by many adenocarcinomas. Antigen-directed cancer surgery using radiolabeled anti-TAG-72 murine monoclonal antibodies (muMAbs) has been previously investigated for colorectal cancer. Survival analysis of primary colorectal cancer patients with a minimum of 15-year follow-up after antigen-directed cancer surgery was performed to assess the impact of complete surgical resection of all detectable radiolabeled anti-TAG-72 muMAb. Methods: Survival analysis was performed on 92 patients (study group) with primary colorectal cancer (July 1990 to August 1995) treated with antigen-directed cancer surgery using 125I-labeled anti-TAG-72 muMAb. The study group was subdivided into those with no detectable TAG-72 antigen-bearing tissues (TAG-72 negative, N = 33) and those with persistent detectable TAG-72 antigen-bearing tissues (TAG-72 positive, N = 59) at completion of surgery. Comparisons were made with a control group (546 patients) from the same time period. Results: Study group and control group were demographically similar, as were TAG-72-negative subgroup and TAG-72-positive subgroup. TAG-72-negative subgroup had significantly improved median survival (8.8 versus 2.5 years; P = 0.005) and time-dependent survival (45.4% versus 22.0% at 10 years; P = 0.002 and 39.4% versus 20.3% at 15 years; P = 0.003) compared with TAG-72-positive subgroup. TAG-72 positivity was as an independent predictor of long-term mortality risk, when controlled for pathologic stage of disease. Conclusions: Absence of detectable TAG-72 antigen within the surgical field at completion of antigen-directed cancer surgery for primary colorectal cancer is of significant prognostic value, conferring a long-term survival advantage to those in whom complete surgical removal of all tissues with detectable radiolabeled anti-TAG-72 muMAb was accomplished.
UR - http://www.scopus.com/inward/record.url?scp=84856665909&partnerID=8YFLogxK
U2 - 10.1245/s10434-011-1880-3
DO - 10.1245/s10434-011-1880-3
M3 - Review article
C2 - 21732140
AN - SCOPUS:84856665909
SN - 1068-9265
VL - 19
SP - 131
EP - 138
JO - Annals of Surgical Oncology
JF - Annals of Surgical Oncology
IS - 1
ER -