Brain Tumor Models for Cancer Therapy

Beverly Teicher; Herbert B. Newton

doi:10.1016/B978-0-12-812100-9.00004-8

Brain Tumor Models for Cancer Therapy

Beverly Teicher
, Herbert B. Newton

Neurology

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Numerous in vitro and animal models have been developed over the years to study the pathology, molecular biology, and response to treatment of brain tumors, especially malignant gliomas. Some of these animal models, including the 9L gliosarcoma, C6 glioma, F98 glioma, and D74-RG2 glioma, will be reviewed in this chapter, in terms of their vasculature and the blood-brain barrier, delivery of therapeutics, including gene therapy and immunological approaches. Boron Neutron Capture Therapy models will also be reviewed. Brain tumor xenograft models will also be discussed in detail in terms of their vasculature and the blood-brain barrier, therapeutic delivery issues, response to chemotherapy, and angiogenesis.

Original language	English
Title of host publication	Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy
Subtitle of host publication	Second Edition
Publisher	Elsevier Inc.
Pages	59-73
Number of pages	15
ISBN (Print)	9780128121009
DOIs	https://doi.org/10.1016/B978-0-12-812100-9.00004-8
State	Published - Apr 24 2018

Keywords

Animal
Brain tumor
Glioblastoma
Glioma
In vitro
Model
Molecular
Xenograft

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10.1016/B978-0-12-812100-9.00004-8

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title = "Brain Tumor Models for Cancer Therapy",

abstract = "Numerous in vitro and animal models have been developed over the years to study the pathology, molecular biology, and response to treatment of brain tumors, especially malignant gliomas. Some of these animal models, including the 9L gliosarcoma, C6 glioma, F98 glioma, and D74-RG2 glioma, will be reviewed in this chapter, in terms of their vasculature and the blood-brain barrier, delivery of therapeutics, including gene therapy and immunological approaches. Boron Neutron Capture Therapy models will also be reviewed. Brain tumor xenograft models will also be discussed in detail in terms of their vasculature and the blood-brain barrier, therapeutic delivery issues, response to chemotherapy, and angiogenesis.",

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AU - Newton, Herbert B.

PY - 2018/4/24

Y1 - 2018/4/24

N2 - Numerous in vitro and animal models have been developed over the years to study the pathology, molecular biology, and response to treatment of brain tumors, especially malignant gliomas. Some of these animal models, including the 9L gliosarcoma, C6 glioma, F98 glioma, and D74-RG2 glioma, will be reviewed in this chapter, in terms of their vasculature and the blood-brain barrier, delivery of therapeutics, including gene therapy and immunological approaches. Boron Neutron Capture Therapy models will also be reviewed. Brain tumor xenograft models will also be discussed in detail in terms of their vasculature and the blood-brain barrier, therapeutic delivery issues, response to chemotherapy, and angiogenesis.

AB - Numerous in vitro and animal models have been developed over the years to study the pathology, molecular biology, and response to treatment of brain tumors, especially malignant gliomas. Some of these animal models, including the 9L gliosarcoma, C6 glioma, F98 glioma, and D74-RG2 glioma, will be reviewed in this chapter, in terms of their vasculature and the blood-brain barrier, delivery of therapeutics, including gene therapy and immunological approaches. Boron Neutron Capture Therapy models will also be reviewed. Brain tumor xenograft models will also be discussed in detail in terms of their vasculature and the blood-brain barrier, therapeutic delivery issues, response to chemotherapy, and angiogenesis.

KW - Animal

KW - Brain tumor

KW - Glioblastoma

KW - Glioma

KW - In vitro

KW - Model

KW - Molecular

KW - Xenograft

UR - https://www.scopus.com/pages/publications/85054686515

U2 - 10.1016/B978-0-12-812100-9.00004-8

DO - 10.1016/B978-0-12-812100-9.00004-8

M3 - Chapter

AN - SCOPUS:85054686515

SN - 9780128121009

SP - 59

EP - 73

BT - Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy

PB - Elsevier Inc.

ER -

Brain Tumor Models for Cancer Therapy

Abstract

Keywords

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