Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

Knut Brockmann; Petra J.W. Pouwels; Peter Dechent; Kevin M. Flanigan; Jens Frahm; Folker Hanefeld

doi:10.1016/s0387-7604(02)00154-7

Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

Knut Brockmann
, Petra J.W. Pouwels
, Peter Dechent
, Kevin M. Flanigan
, Jens Frahm
, Folker Hanefeld

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

Original language	English
Pages (from-to)	45-50
Number of pages	6
Journal	Brain and Development
Volume	25
Issue number	1
DOIs	https://doi.org/10.1016/s0387-7604(02)00154-7
State	Published - Jan 2003

Keywords

Demyelination
Giant axonal neuropathy
Leukoencephalopathy
Magnetic resonance spectroscopy

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10.1016/s0387-7604(02)00154-7

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title = "Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy",

abstract = "Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.",

keywords = "Demyelination, Giant axonal neuropathy, Leukoencephalopathy, Magnetic resonance spectroscopy",

author = "Knut Brockmann and Pouwels, \{Petra J.W.\} and Peter Dechent and Flanigan, \{Kevin M.\} and Jens Frahm and Folker Hanefeld",

note = "Funding Information: P.J.W.P. was supported by a fellowship of the European Community (ERBCH-BGCT 940722).",

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T1 - Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

AU - Brockmann, Knut

AU - Pouwels, Petra J.W.

AU - Dechent, Peter

AU - Flanigan, Kevin M.

AU - Frahm, Jens

AU - Hanefeld, Folker

N1 - Funding Information: P.J.W.P. was supported by a fellowship of the European Community (ERBCH-BGCT 940722).

PY - 2003/1

Y1 - 2003/1

N2 - Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

AB - Magnetic resonance imaging of a girl with giant axonal neuropathy revealed a progressive white matter disease. In close agreement with histopathological features reported previously, localized proton magnetic resonance spectroscopy at 9 and 12 years of age indicated a specific damage or loss of axons (reduced N-acetylaspartate and N-acetylaspartylglutamate) accompanied by acute demyelination (elevated choline-containing compounds, myo-inositol, and lactate) in white matter as well as a generalized proliferation of glial cells (elevated choline-containing compounds and myo-inositol) in both gray and white matter.

KW - Demyelination

KW - Giant axonal neuropathy

KW - Leukoencephalopathy

KW - Magnetic resonance spectroscopy

UR - https://www.scopus.com/pages/publications/0037245448

U2 - 10.1016/s0387-7604(02)00154-7

DO - 10.1016/s0387-7604(02)00154-7

M3 - Article

C2 - 12536033

AN - SCOPUS:0037245448

SN - 0387-7604

VL - 25

SP - 45

EP - 50

JO - Brain and Development

JF - Brain and Development

IS - 1

ER -

Cerebral proton magnetic resonance spectroscopy of a patient with giant axonal neuropathy

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Keywords

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