Chemogenomics approach to understanding drug-transporter interactions

Wolfgang Sadée

Chemogenomics approach to understanding drug-transporter interactions

Wolfgang Sadée

Research output: Contribution to journal › Article › peer-review

Abstract

We have applied two approaches to understanding the role of membrane transporters in drug action. First, we correlate gene expression with cytotoxic drug potencies, leading to the identification of drug-transporter interactions relevant to cancer chemotherapy. Second, we search for functional polymorphisms in transporter genes, yielding new insight into genetic causes of interindividual variability of drug response.

Original language	English
Pages (from-to)	27-29
Number of pages	3
Journal	Acta Biomedica de l'Ateneo Parmense
Volume	77
Issue number	SUPPL. 3
State	Published - Dec 12 2006

Keywords

Genetic polymorphisms
Pharmacogenomics
Structure-activity relationships
Transporter genes

Cite this

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title = "Chemogenomics approach to understanding drug-transporter interactions",

abstract = "We have applied two approaches to understanding the role of membrane transporters in drug action. First, we correlate gene expression with cytotoxic drug potencies, leading to the identification of drug-transporter interactions relevant to cancer chemotherapy. Second, we search for functional polymorphisms in transporter genes, yielding new insight into genetic causes of interindividual variability of drug response.",

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AB - We have applied two approaches to understanding the role of membrane transporters in drug action. First, we correlate gene expression with cytotoxic drug potencies, leading to the identification of drug-transporter interactions relevant to cancer chemotherapy. Second, we search for functional polymorphisms in transporter genes, yielding new insight into genetic causes of interindividual variability of drug response.

KW - Genetic polymorphisms

KW - Pharmacogenomics

KW - Structure-activity relationships

KW - Transporter genes

UR - https://www.scopus.com/pages/publications/33845332011

M3 - Article

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SN - 0392-4203

VL - 77

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JO - Acta Biomedica de l'Ateneo Parmense

JF - Acta Biomedica de l'Ateneo Parmense

IS - SUPPL. 3

ER -

Chemogenomics approach to understanding drug-transporter interactions

Abstract

Keywords

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