Discovery of anticancer agents of diverse natural origin

A. Douglas Kinghorn; Esperanza J. Carcache De Blanco; David M. Lucas; H. Liva Rakotondraibe; Jimmy Orjala; D. Doel Soejarto; Nicholas H. Oberlies; Cedric J. Pearce; Mansukh C. Wani; Brent R. Stockwell; Joanna E. Burdette; Steven M. Swanson; James R. Fuchs; Mitchell A. Phelps; Lihui Xu; Xiaoli Zhang; Young Yongchun Shen

doi:10.21873/anticanres.11146

Discovery of anticancer agents of diverse natural origin

A. Douglas Kinghorn, Esperanza J. Carcache De Blanco, David M. Lucas, H. Liva Rakotondraibe, Jimmy Orjala, D. Doel Soejarto, Nicholas H. Oberlies, Cedric J. Pearce, Mansukh C. Wani, Brent R. Stockwell, Joanna E. Burdette, Steven M. Swanson, James R. Fuchs, Mitchell A. Phelps, Lihui Xu, Xiaoli Zhang, Young Yongchun Shen

Research output: Contribution to journal › Review article › peer-review

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Abstract

Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.

Original language	English
Pages (from-to)	5623-5637
Number of pages	15
Journal	Anticancer research
Volume	36
Issue number	11
DOIs	https://doi.org/10.21873/anticanres.11146
State	Published - Nov 2016

Keywords

Cyanobacteria
Fungi
Natural products
Potential anticancer activity
Review
Tropical plants

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10.21873/anticanres.11146

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Kinghorn, A. D., Carcache De Blanco, E. J., Lucas, D. M., Rakotondraibe, H. L., Orjala, J., Soejarto, D. D., Oberlies, N. H., Pearce, C. J., Wani, M. C., Stockwell, B. R., Burdette, J. E., Swanson, S. M., Fuchs, J. R., Phelps, M. A., Xu, L., Zhang, X., & Shen, Y. Y. (2016). Discovery of anticancer agents of diverse natural origin. Anticancer research, 36(11), 5623-5637. https://doi.org/10.21873/anticanres.11146

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title = "Discovery of anticancer agents of diverse natural origin",

abstract = "Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.",

keywords = "Cyanobacteria, Fungi, Natural products, Potential anticancer activity, Review, Tropical plants",

author = "Kinghorn, {A. Douglas} and {Carcache De Blanco}, {Esperanza J.} and Lucas, {David M.} and Rakotondraibe, {H. Liva} and Jimmy Orjala and Soejarto, {D. Doel} and Oberlies, {Nicholas H.} and Pearce, {Cedric J.} and Wani, {Mansukh C.} and Stockwell, {Brent R.} and Burdette, {Joanna E.} and Swanson, {Steven M.} and Fuchs, {James R.} and Phelps, {Mitchell A.} and Lihui Xu and Xiaoli Zhang and Shen, {Young Yongchun}",

year = "2016",

month = nov,

doi = "10.21873/anticanres.11146",

language = "English",

volume = "36",

pages = "5623--5637",

journal = "Anticancer research",

issn = "0250-7005",

number = "11",

}

Kinghorn, AD, Carcache De Blanco, EJ, Lucas, DM, Rakotondraibe, HL, Orjala, J, Soejarto, DD, Oberlies, NH, Pearce, CJ, Wani, MC, Stockwell, BR, Burdette, JE, Swanson, SM, Fuchs, JR, Phelps, MA, Xu, L, Zhang, X & Shen, YY 2016, 'Discovery of anticancer agents of diverse natural origin', Anticancer research, vol. 36, no. 11, pp. 5623-5637. https://doi.org/10.21873/anticanres.11146

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AU - Kinghorn, A. Douglas

AU - Carcache De Blanco, Esperanza J.

AU - Lucas, David M.

AU - Rakotondraibe, H. Liva

AU - Orjala, Jimmy

AU - Soejarto, D. Doel

AU - Oberlies, Nicholas H.

AU - Pearce, Cedric J.

AU - Wani, Mansukh C.

AU - Stockwell, Brent R.

AU - Burdette, Joanna E.

AU - Swanson, Steven M.

AU - Fuchs, James R.

AU - Phelps, Mitchell A.

AU - Xu, Lihui

AU - Zhang, Xiaoli

AU - Shen, Young Yongchun

PY - 2016/11

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AB - Recent progress is described in an ongoing collaborative multidisciplinary research project directed towards the purification, structural characterization, chemical modification, and biological evaluation of new potential natural product anticancer agents obtained from a diverse group of organisms, comprising tropical plants, aquatic and terrestrial cyanobacteria, and filamentous fungi. Information is provided on how these organisms are collected and processed. The types of bioassays are indicated in which initial extracts, chromatographic fractions, and purified isolated compounds of these acquisitions are tested. Several promising biologically active lead compounds from each major organism class investigated are described, and these may be seen to be representative of a very wide chemical diversity.

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KW - Natural products

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SN - 0250-7005

VL - 36

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JO - Anticancer research

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Discovery of anticancer agents of diverse natural origin

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