DNA translocation dynamics through short nanochannels under asymmetric pulsed electric field

Cherry Gupta, Wei Ching Liao, Daniel Gallego-Perez, Carlos E. Castro, L. James Lee

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

We present our work on DNA dynamics in short polymeric nanochannels under pulsed electric fields and simulate their behavior using Brownian Dynamics. Our results show that the time taken by a DNA molecule to traverse a short nanochannel varies non-linearly with the applied voltage and depends on the length of the translocating DNA. We exploit this to separate two DNA of different lengths by applying an asymmetric electrical pulse.

Original languageEnglish
Title of host publication17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
PublisherChemical and Biological Microsystems Society
Pages817-819
Number of pages3
ISBN (Print)9781632666246
StatePublished - 2013
Event17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013 - Freiburg, Germany
Duration: Oct 27 2013Oct 31 2013

Publication series

Name17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Volume2

Other

Other17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013
Country/TerritoryGermany
CityFreiburg
Period10/27/1310/31/13

Keywords

  • DNA dynamics
  • DNA separation
  • Nanofluidics

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