Efficient and scalable synthesis of 4-carboxy-pennsylvania green methyl ester: A hydrophobic building block for fluorescent molecular probes

Keyphrases

• Pennsylvania 100%
• Efficient Synthesis 100%
• Methyl Ester 100%
• Fluorescent Molecular Probes 100%
• Scalable Synthesis 100%
• Fluorophore 50%
• Amines 50%
• Fluorinated 50%
• Biological Systems 25%
• Endosome 25%
• Cellular Compartments 25%
• Chromatography 25%
• Chemical Biology 25%
• Cell Permeable 25%
• Intracellular Targets 25%
• Intracellular Components 25%
• Esters 25%
• Hydroxide 25%
• PK a 25%
• Tokyo 25%
• Overall Yield 25%
• Oregon Green 25%
• Single Isomer 25%
• Difluoro 25%
• Quantitative Yield 25%
• Reactive N 25%
• Methanone 25%
• Nucleophilic Aromatic Substitution 25%
• Practical Synthesis 25%

Chemistry

• Methyl Ester 100%
• Molecular Probe 100%
• Purity 33%
• Dissociation Exponent 33%
• Quantitative Yield 33%
• Nucleophilic Aromatic Substitution 33%

Biochemistry, Genetics and Molecular Biology

• Molecular Probe 100%
• Nucleophilicity 50%