TY - JOUR
T1 - Exploring the manifestations of anxiety in children with autism spectrum disorders
AU - Hallett, Victoria
AU - Lecavalier, Luc
AU - Sukhodolsky, Denis G.
AU - Cipriano, Noreen
AU - Aman, Michael G.
AU - McCracken, James T.
AU - McDougle, Christopher J.
AU - Tierney, Elaine
AU - King, Bryan H.
AU - Hollander, Eric
AU - Sikich, Linmarie
AU - Bregman, Joel
AU - Anagnostou, Evdokia
AU - Donnelly, Craig
AU - Katsovich, Lily
AU - Dukes, Kimberly
AU - Vitiello, Benedetto
AU - Gadow, Kenneth
AU - Scahill, Lawrence
N1 - Funding Information:
Acknowledgments The authors acknowledge Ann Wagner, PhD and Louise Ritz, MBA at NIMH; James Robinson, MED, at NKI; Mark Davies, MPH at NY State Psychiatric Institute, Stacey Grinnon, MA at KAI Research, Inc; Deborah Hirtz MD at the National Institute of Neurological Disorders and Stroke, Bethesda, Lisa Sullivan, PhD at Boston University; Fay Robinson, MPH at DMSTAT and James Dziura, PhD, Sunkyung Yu, MS, Yanhong Deng, MPH and Allison Gavaletz, BS at Yale University. The RUPP studies were funded by the following NIMH grants and contracts: N01MH70009 and U10MH66764 (Yale); N01MH70001 and U10MH66766 (Indiana University); N01MH80011 and U10MH66768 (Ohio State University); N01MH70010 (UCLA). This publication was also supported by the Yale Clinical and Translational Science Award (CTSA) UL1RR024139, Indiana University CTSA UL1 RR025761, and Ohio State University CTSA UL1 RR025755 from the National Center for Research Resources (NCRR). The STAART citalopram study was funded by NIH via the following center contracts: Mount Sinai School of Medicine: U54-MH066673; University of North Carolina at ChapelHill: U54-MH066418; University of California at Los Angeles: U54-MH068172; Yale University: U54-MH066494. Dartmouth Medical School and Boston University: U54-MH066398; and DM-STAT, Inc, Boston: U01-HD045023.
PY - 2013/10
Y1 - 2013/10
N2 - This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement.
AB - This study explores the manifestation and measurement of anxiety symptoms in 415 children with ASDs on a 20-item, parent-rated, DSM-IV referenced anxiety scale. In both high and low-functioning children (IQ above vs. below 70), commonly endorsed items assessed restlessness, tension and sleep difficulties. Items requiring verbal expression of worry by the child were rarely endorsed. Higher anxiety was associated with functional language, IQ above 70 and higher scores on several other behavioral measures. Four underlying factors emerged: Generalized Anxiety, Separation Anxiety, Social Anxiety and Over-arousal. Our findings extend our understanding of anxiety across IQ in ASD and provide guidance for improving anxiety outcome measurement.
KW - Anxiety
KW - Autism spectrum disorders
KW - Clinical Trials
KW - Measurement
UR - https://www.scopus.com/pages/publications/84884986781
U2 - 10.1007/s10803-013-1775-1
DO - 10.1007/s10803-013-1775-1
M3 - Article
C2 - 23400347
AN - SCOPUS:84884986781
SN - 0162-3257
VL - 43
SP - 2341
EP - 2352
JO - Journal of Autism and Developmental Disorders
JF - Journal of Autism and Developmental Disorders
IS - 10
ER -