Genetic Loss of miR-205 Causes Increased Mammary Gland Development

Alessandra Cataldo; Douglas G. Cheung; John P. Hagan; Matteo Fassan; Sukhinder Sandhu-Deol; Carlo M. Croce; Gianpiero Di Leva; Marilena V. Iorio

doi:10.3390/ncrna10010004

Genetic Loss of miR-205 Causes Increased Mammary Gland Development

Alessandra Cataldo, Douglas G. Cheung, John P. Hagan, Matteo Fassan, Sukhinder Sandhu-Deol, Carlo M. Croce, Gianpiero Di Leva, Marilena V. Iorio

Research output: Contribution to journal › Article › peer-review

Abstract

MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205^−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.

Original language	English
Article number	4
Journal	Non-coding RNA
Volume	10
Issue number	1
DOIs	https://doi.org/10.3390/ncrna10010004
State	Published - Feb 2024

Keywords

breast cancer
mammary gland
microRNA

Access to Document

10.3390/ncrna10010004

Cite this

@article{85447a58f5c64c6ebe21b39be52164bb,

title = "Genetic Loss of miR-205 Causes Increased Mammary Gland Development",

abstract = "MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.",

keywords = "breast cancer, mammary gland, microRNA",

author = "Alessandra Cataldo and Cheung, {Douglas G.} and Hagan, {John P.} and Matteo Fassan and Sukhinder Sandhu-Deol and Croce, {Carlo M.} and {Di Leva}, Gianpiero and Iorio, {Marilena V.}",

note = "Publisher Copyright: {\textcopyright} 2023 by the authors.",

year = "2024",

month = feb,

doi = "10.3390/ncrna10010004",

language = "English",

volume = "10",

journal = "Non-coding RNA",

issn = "2311-553X",

number = "1",

}

TY - JOUR

T1 - Genetic Loss of miR-205 Causes Increased Mammary Gland Development

AU - Cataldo, Alessandra

AU - Cheung, Douglas G.

AU - Hagan, John P.

AU - Fassan, Matteo

AU - Sandhu-Deol, Sukhinder

AU - Croce, Carlo M.

AU - Di Leva, Gianpiero

AU - Iorio, Marilena V.

PY - 2024/2

Y1 - 2024/2

N2 - MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.

AB - MiRNAs play crucial roles in a broad spectrum of biological processes, both physiological and pathological. Different reports implicate miR-205 in the control of breast stem cell properties. Differential miR-205 expression has been observed in different stages of mammary gland development and maturation. However, a functional role in this process has not been clearly demonstrated. We generated an miR-205 knockout in the FVB/N mouse strain, which is viable and characterized by enhanced mammary gland development. Indeed, mammary glands of miR-205−/− female mice at different ages (1.5 and 5.5 months) show increased outgrowth and branching. This evidence is consistent with our previously reported data demonstrating the direct miR-205-mediated targeting of HER3, a master regulator of mammary gland development, and the oncosuppressive activity of this microRNA in different types of breast cancer.

KW - breast cancer

KW - mammary gland

KW - microRNA

UR - http://www.scopus.com/inward/record.url?scp=85185909287&partnerID=8YFLogxK

U2 - 10.3390/ncrna10010004

DO - 10.3390/ncrna10010004

M3 - Article

AN - SCOPUS:85185909287

SN - 2311-553X

VL - 10

JO - Non-coding RNA

JF - Non-coding RNA

IS - 1

M1 - 4

ER -

Genetic Loss of miR-205 Causes Increased Mammary Gland Development

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this