TY - GEN
T1 - High-throughput continuous magnetic sorting of unlabeled red blood Cells (RBC) and analysis by cell tracking velocimetry (CTV)
AU - Chalmers, Jeffrey J.
AU - Xu, Jie
AU - Jin, Xiaoxia
AU - Moore, Lee
AU - Zborowski, Maciej
N1 - Funding Information:
Jeffrey J. Chalmers1, Jie Xu1, Xiaoxia Jin2, Lee Moore2 and Maciej Zborowski3, (1)Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, (2)Biomedical Engineering, Cleveland Clinic, Cleveland, OH, (3) Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH We have designed and are developing a continuous magnetic sorter that can process up to 1011RBCs in 24 hours from a bioreactor, producing these RBC. This research is part of a much larger project, sponsored by DARPA, to produce a portable, self-renewing supply of blood transfusions for battlefield casualties, i.e. “blood Pharming”. These RBCs are produced from hematopoetic stem cells isolated from human placenta; allowed to grow in an undifferentiated state for many generations, and finally induced to produce mature RBC. Since cells grow at different rates, and do not necessarily differentiate all at the same time, mature RBCs must be continually removed from culture.
PY - 2011
Y1 - 2011
UR - https://www.scopus.com/pages/publications/85054800248
M3 - Conference contribution
AN - SCOPUS:85054800248
SN - 9781618397232
T3 - Separations Division - Core Programming Topic at the 2011 AIChE Annual Meeting
SP - 920
EP - 921
BT - Separations Division - Core Programming Topic at the 2011 AIChE Annual Meeting
PB - AIChE
T2 - Separations Division - Core Programming Topic at the 2011 AIChE Annual Meeting
Y2 - 16 October 2011 through 21 October 2011
ER -