TY - GEN
T1 - Immune modulation with interleukin-21
AU - Bhave, Neela S.
AU - Carson, William E.
PY - 2009
Y1 - 2009
N2 - Interleukin 21 (IL-21) is produced by activated CD4+ T cells. The IL-21R shares the common receptor gamma-chain with IL-2, IL-4, IL-7, IL-9, and IL-15, is widely expressed on immune cells, and mediates a variety of effects on the immune system. IL-21 enhances the proliferation, antigen-induced activation, clonal expansion, IFN-γ production, and cytotoxicity of NK cells and T cells. The antitumor actions of IL-21 have been variously attributed to NK cell and CD8+ T cell cytotoxicity, CD4+ T cell help, NKT cells, and the antiangiogenic properties induced by IFN-γ secretion. In clinical trials IL-21 has been well tolerated and induces a unique pattern of immune activation. IL-21 is therefore an excellent candidate for use in immune therapy.
AB - Interleukin 21 (IL-21) is produced by activated CD4+ T cells. The IL-21R shares the common receptor gamma-chain with IL-2, IL-4, IL-7, IL-9, and IL-15, is widely expressed on immune cells, and mediates a variety of effects on the immune system. IL-21 enhances the proliferation, antigen-induced activation, clonal expansion, IFN-γ production, and cytotoxicity of NK cells and T cells. The antitumor actions of IL-21 have been variously attributed to NK cell and CD8+ T cell cytotoxicity, CD4+ T cell help, NKT cells, and the antiangiogenic properties induced by IFN-γ secretion. In clinical trials IL-21 has been well tolerated and induces a unique pattern of immune activation. IL-21 is therefore an excellent candidate for use in immune therapy.
KW - Innate immunity
KW - Interleukin-21
KW - NK cells
KW - Tumor immunology
UR - http://www.scopus.com/inward/record.url?scp=73849140105&partnerID=8YFLogxK
U2 - 10.1111/j.1749-6632.2009.05071.x
DO - 10.1111/j.1749-6632.2009.05071.x
M3 - Conference contribution
C2 - 20074273
AN - SCOPUS:73849140105
SN - 9781573317832
T3 - Annals of the New York Academy of Sciences
SP - 39
EP - 46
BT - Cytokine Therapies Novel Approaches for Clinical Indications
PB - Blackwell Publishing Inc.
ER -