Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20: Evidence against synteny

Lindsay A. Farrer; Paul J. Goodfellow; Bradley N. White; Jeanette J.A. Holden; Judith R. Kidd; Nancy E. Simpson; Kenneth K. Kidd

doi:10.1016/0165-4608(87)90015-X

Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20: Evidence against synteny

Lindsay A. Farrer
, Paul J. Goodfellow
, Bradley N. White
, Jeanette J.A. Holden
, Judith R. Kidd
, Nancy E. Simpson
, Kenneth K. Kidd

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Members of four families in which multiple endocrine neoplasia type 2A (MEN-2A) is segregating were genotyped for three chromosome #20 DNA markers. Close linkage is excluded for the genetic locus of MEN-2A (MEN2A) with each marker locus tested. Using multipoint analysis, the MEN2A locus was excluded from a region 32.5 cM in length encompassing D20S5 and D20S6, two loci that previously had been mapped to the chromosome 20p12.2 region containing the putative deletion associated with MEN-2. In total, we excluded approximately 90.5 cM of chromosome #20 as a possible location of the MEN2A locus. The data from this study do not support increased recombination on the short arms of chromosome #20 and were insufficient to support heterogeneity of MEN-2A as possible explanations for failure to detect linkage between MEN2A and D20S5 or D20S6.

Original language	English
Pages (from-to)	327-334
Number of pages	8
Journal	Cancer Genetics and Cytogenetics
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(87)90015-X
State	Published - Aug 1987

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@article{67363ff60f6c4a5ca9b1198d260ba8c4,

title = "Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20: Evidence against synteny",

abstract = "Members of four families in which multiple endocrine neoplasia type 2A (MEN-2A) is segregating were genotyped for three chromosome \#20 DNA markers. Close linkage is excluded for the genetic locus of MEN-2A (MEN2A) with each marker locus tested. Using multipoint analysis, the MEN2A locus was excluded from a region 32.5 cM in length encompassing D20S5 and D20S6, two loci that previously had been mapped to the chromosome 20p12.2 region containing the putative deletion associated with MEN-2. In total, we excluded approximately 90.5 cM of chromosome \#20 as a possible location of the MEN2A locus. The data from this study do not support increased recombination on the short arms of chromosome \#20 and were insufficient to support heterogeneity of MEN-2A as possible explanations for failure to detect linkage between MEN2A and D20S5 or D20S6.",

author = "Farrer, \{Lindsay A.\} and Goodfellow, \{Paul J.\} and White, \{Bradley N.\} and Holden, \{Jeanette J.A.\} and Kidd, \{Judith R.\} and Simpson, \{Nancy E.\} and Kidd, \{Kenneth K.\}",

note = "Funding Information: Supported by USPHS Grant CA32066 (K. K. K.), a Canadian MRC Grant MT5783 (N. E. S.), a National Cancer Institute grant (N. E. S., B. N. W., and J. J. A. H.). L. A. F. is supported by PHS Award 2T32MH14235.",

year = "1987",

month = aug,

doi = "10.1016/0165-4608(87)90015-X",

language = "English",

volume = "27",

pages = "327--334",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

number = "2",

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TY - JOUR

T1 - Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20

T2 - Evidence against synteny

AU - Farrer, Lindsay A.

AU - Goodfellow, Paul J.

AU - White, Bradley N.

AU - Holden, Jeanette J.A.

AU - Kidd, Judith R.

AU - Simpson, Nancy E.

AU - Kidd, Kenneth K.

N1 - Funding Information: Supported by USPHS Grant CA32066 (K. K. K.), a Canadian MRC Grant MT5783 (N. E. S.), a National Cancer Institute grant (N. E. S., B. N. W., and J. J. A. H.). L. A. F. is supported by PHS Award 2T32MH14235.

PY - 1987/8

Y1 - 1987/8

N2 - Members of four families in which multiple endocrine neoplasia type 2A (MEN-2A) is segregating were genotyped for three chromosome #20 DNA markers. Close linkage is excluded for the genetic locus of MEN-2A (MEN2A) with each marker locus tested. Using multipoint analysis, the MEN2A locus was excluded from a region 32.5 cM in length encompassing D20S5 and D20S6, two loci that previously had been mapped to the chromosome 20p12.2 region containing the putative deletion associated with MEN-2. In total, we excluded approximately 90.5 cM of chromosome #20 as a possible location of the MEN2A locus. The data from this study do not support increased recombination on the short arms of chromosome #20 and were insufficient to support heterogeneity of MEN-2A as possible explanations for failure to detect linkage between MEN2A and D20S5 or D20S6.

AB - Members of four families in which multiple endocrine neoplasia type 2A (MEN-2A) is segregating were genotyped for three chromosome #20 DNA markers. Close linkage is excluded for the genetic locus of MEN-2A (MEN2A) with each marker locus tested. Using multipoint analysis, the MEN2A locus was excluded from a region 32.5 cM in length encompassing D20S5 and D20S6, two loci that previously had been mapped to the chromosome 20p12.2 region containing the putative deletion associated with MEN-2. In total, we excluded approximately 90.5 cM of chromosome #20 as a possible location of the MEN2A locus. The data from this study do not support increased recombination on the short arms of chromosome #20 and were insufficient to support heterogeneity of MEN-2A as possible explanations for failure to detect linkage between MEN2A and D20S5 or D20S6.

UR - https://www.scopus.com/pages/publications/0023221375

U2 - 10.1016/0165-4608(87)90015-X

DO - 10.1016/0165-4608(87)90015-X

M3 - Article

C2 - 2885081

AN - SCOPUS:0023221375

SN - 0165-4608

VL - 27

SP - 327

EP - 334

JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

Linkage analysis of multiple endocrine neoplasia type 2A (MEN-2A) and three DNA markers on chromosome 20: Evidence against synteny

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