TY - JOUR
T1 - Longitudinal Design for Sonographic Measurement of Median Nerve Swelling with Controlled Exposure to Physical Work Using an Animal Model
AU - Roll, Shawn C.
AU - Evans, Kevin D.
AU - Volz, Kevin R.
AU - Sommerich, Carolyn M.
N1 - Funding Information:
The authors thank John A. Buford for the laboratory support required to conduct this research. This work was supported in part by National Institute of Occupational Safety and Health Grants R01 OH009131 and R21 OH009907 . Shawn C. Roll was funded by National Institutes of Health Rehabilitation Research Career Development Program Grant K12 HD055929 at the time this article was prepared. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH.
PY - 2013/12
Y1 - 2013/12
N2 - In the study described here, we examined the feasibility of a longitudinal design to measure sonographically swelling of the median nerve caused by controlled exposure to a work task and to evaluate the relationship of changes in morphology to diagnostic standards. Fifteen macaques, Macaca fascicularis, pinched a lever in various wrist positions at a self-regulated pace (8 h/d, 5 d/wk, 18-20 wk). Nerve conduction velocity (NCV) and cross-sectional area (CSA) were measured every 2 wk from baseline through working and a 6-wk recovery. Trending across all subjects revealed that NCV slowed and CSA at the carpal tunnel increased in the working arm, whereas no changes were observed in CSA either at the forearm or for any measure in the non-working arm. There was a small negative correlation between NCV and CSA in the working arm. This study provides validation that swelling can be observed using a longitudinal design. Longitudinal human studies are needed to describe the trajectory of nerve swelling for early identification of median nerve pathology.
AB - In the study described here, we examined the feasibility of a longitudinal design to measure sonographically swelling of the median nerve caused by controlled exposure to a work task and to evaluate the relationship of changes in morphology to diagnostic standards. Fifteen macaques, Macaca fascicularis, pinched a lever in various wrist positions at a self-regulated pace (8 h/d, 5 d/wk, 18-20 wk). Nerve conduction velocity (NCV) and cross-sectional area (CSA) were measured every 2 wk from baseline through working and a 6-wk recovery. Trending across all subjects revealed that NCV slowed and CSA at the carpal tunnel increased in the working arm, whereas no changes were observed in CSA either at the forearm or for any measure in the non-working arm. There was a small negative correlation between NCV and CSA in the working arm. This study provides validation that swelling can be observed using a longitudinal design. Longitudinal human studies are needed to describe the trajectory of nerve swelling for early identification of median nerve pathology.
KW - Carpal tunnel syndrome
KW - Median mononeuropathy
KW - Sonography
UR - https://www.scopus.com/pages/publications/84887822768
U2 - 10.1016/j.ultrasmedbio.2013.08.008
DO - 10.1016/j.ultrasmedbio.2013.08.008
M3 - Article
C2 - 24139197
AN - SCOPUS:84887822768
SN - 0301-5629
VL - 39
SP - 2492
EP - 2497
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
IS - 12
ER -