@article{72d0a0a18a0e49f9b122fb3cbf60edf2,
title = "Marked decline in serum digoxin concentrations during an episode of severe diarrhea",
author = "Kolibash, \{Albert J.\} and Kramer, \{William G.\} and Reuning, \{Richard H.\} and Caldwell, \{James H.\}",
note = "Funding Information: During the past several years numerous studies involving digoxin pharmacokinetics and bioavailability have been reported.l \textasciitilde{} However, relatively few studies have been directed to the actual mechanism of digoxin absorption and in particular to the influence of factors such as altered intestinal motility and transit time, 3 intestinal disease, 4-6 and the role of the enterohepatic circulationY. 8 From these studies it does seem apparent that disturbances of normal gastrointestinal function might well result in a significant alteration of digoxm bioavailability. We would like to report such a circumstance involving an individual who demonstrated profound differences in serum digoxin levels during an acute transient diarrheal illnesS. A 24-year-old healthy male volunteer received four 0.25 rag. digoxin tablets (Lanoxin. Burroughs Welcome, Lot 022-1) as part of a more extensive study of digoxin absorption and *This study was supported in part by grants from the Central Ohio Heart Chapter of the American Heart Association. the National Heart and Lung Institute training grant No. 5 T01 HL05968. the Clinical Research Center of the Ohio State University, Philips Roxane Laboratories, and Medicinal Chemistry Training grant GM-1949 \{NIH).",
year = "1977",
month = dec,
doi = "10.1016/S0002-8703(77)80225-1",
language = "English",
volume = "94",
pages = "806--807",
journal = "American Heart Journal",
issn = "0002-8703",
number = "6",
}