TY - JOUR
T1 - Maternal-fetal DNA admixture is associated with intrapartum mother-to-child transmission of HIV-1 in Blantyre, Malawi
AU - Kwiek, Jesse J.
AU - Arney, Leslie A.
AU - Harawa, Visopo
AU - Pedersen, Bonnie
AU - Mwapasa, Victor
AU - Rogerson, Stephen J.
AU - Meshnick, Steven R.
N1 - Funding Information:
Financial support: National Institutes of Health (K99-HD056586 and R00-HD056586 to J.J.K.; R01-TW007305 to V.M.; R01-AI49084 and R21-AI065369 to S.R.M.); University of North Carolina Center For AIDS Research (P30-AI50410); Wellcome Trust (Senior Fellowship to S.J.R.) The funding agencies had no role in study design, data collection, data analysis, decision to publish, or preparation of the manuscript, and the content does not necessarily represent the official views of the National Institute of Child Health and Human Development, the National Institute of Allergy and Infectious Diseases, or the National Institutes of Health.
Funding Information:
We thank the Malawian women and their infants for their consent and participation; the study nurses and laboratory technicians for their excellent support; and the UNC Center for AIDS Research for their financial assistance.
PY - 2008/5/15
Y1 - 2008/5/15
N2 - Background. The mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described. Methods. Of 328 HIV-infected mother-infant pairs, we identified 91 that had discordant angiotensin I-converting enzyme and glutathione S-transferase M1 alleles. Maternal alleles in cord blood were quantified with real-time polymerase chain reaction, as indicators of microtransfusions. Results. HIV-1 infected infants had more maternal DNA in cord blood than their uninfected counterparts. Increased maternal DNA in cord blood was associated with preterm delivery, low birth weight, and maternal immunosuppression. Conclusion. Intrapartum MTCT was associated with placental microtransfusions. The associations among placental microtransfusion, in-utero MTCT, maternal immunosuppression, and poor birth outcome should be further investigated.
AB - Background. The mechanism of mother-to-child transmission (MTCT) of HIV-1 is not well described. Methods. Of 328 HIV-infected mother-infant pairs, we identified 91 that had discordant angiotensin I-converting enzyme and glutathione S-transferase M1 alleles. Maternal alleles in cord blood were quantified with real-time polymerase chain reaction, as indicators of microtransfusions. Results. HIV-1 infected infants had more maternal DNA in cord blood than their uninfected counterparts. Increased maternal DNA in cord blood was associated with preterm delivery, low birth weight, and maternal immunosuppression. Conclusion. Intrapartum MTCT was associated with placental microtransfusions. The associations among placental microtransfusion, in-utero MTCT, maternal immunosuppression, and poor birth outcome should be further investigated.
UR - https://www.scopus.com/pages/publications/43949097228
U2 - 10.1086/587646
DO - 10.1086/587646
M3 - Article
C2 - 18444794
AN - SCOPUS:43949097228
SN - 0022-1899
VL - 197
SP - 1378
EP - 1381
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -