TY - JOUR
T1 - Mechanisms of NOD-like receptor-associated inflammasome activation
AU - Wen, Haitao
AU - Miao, Edward A.
AU - Ting, Jenny P.Y.
N1 - Funding Information:
This work was supported by National Institutes of Health grants R37-AI029564, U54-AI057157 (SERCEB), U19AI077437, U19AI067798, and CA156330 awarded to J.P.-Y.T., NIH grants AI097518 and AI057141 awarded to E.A.M., and NIH grant K01DK098307 awarded to H.W. H.W. is a recipient of Postdoctoral Fellowship of the American Heart Association (Mid-Atlantic Affiliate) and Postdoctoral Fellowship of Cancer Research Institute. We thank M. Moayeri for helpful discussions.
PY - 2013/9/19
Y1 - 2013/9/19
N2 - A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
AB - A major function of a subfamily of NLR (nucleotide-binding domain, leucine-rich repeat containing, or NOD-like receptor) proteins is in inflammasome activation, which has been implicated in a multitude of disease models and human diseases. This work will highlight key progress in understanding the mechanisms that activate the best-studied NLRs (NLRP3, NLRC4, NAIP, and NLRP1) and in uncovering inflammasome NLRs.
UR - http://www.scopus.com/inward/record.url?scp=84884332722&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2013.08.037
DO - 10.1016/j.immuni.2013.08.037
M3 - Review article
C2 - 24054327
AN - SCOPUS:84884332722
SN - 1074-7613
VL - 39
SP - 432
EP - 441
JO - Immunity
JF - Immunity
IS - 3
ER -