@inproceedings{337ff52a927f4c87a5146d2f8e4644a5,
title = "Nanoporous delivery devices based on biodegradable polymers for constant drug release",
abstract = "A particulate-like miniature device made of biodegradable polymers has been developed to provide drug protection and constant delivery. The main part of the device is a nanoporous controlled gate and a fabricated drug reservoir loaded with a therapeutic agent. A method to create nanoporous composite membranes via phase inversion has been described to prepare the controlled gate. A small amount of Na-montmorillonite was used as additive to stabilize the membrane structure and improve the diffusion of hydrophilic molecules through the membrane. To improve the biocompatibility of the devices, a hydrophilic poly(ethylene glycol) diacrylate was coated onto the device surface by UV-polymerization. Carbon dioxide (CO2)-assisted bonding was applied for device assembling to minimize the negative effect of the manufacturing process on the protein bioactivity. The constant release has been successfully demonstrated in vitro using a Costar Transwell setup.",
author = "Hongyan He and Chi Yen and Natalie Jones and Winston Ho and Carson, {William E.} and Lee, {L. James}",
year = "2007",
language = "English",
isbn = "9780816910229",
series = "AIChE Annual Meeting, Conference Proceedings",
booktitle = "2007 AIChE Annual Meeting",
note = "2007 AIChE Annual Meeting ; Conference date: 04-11-2007 Through 09-11-2007",
}