N,N-Dimethylglycine for Epilepsy

Victor Herbert; E. Steve Roach; Lane Carlin

doi:10.1056/NEJM198303033080919

N,N-Dimethylglycine for Epilepsy

Victor Herbert
, E. Steve Roach
, Lane Carlin

Pediatrics

Research output: Contribution to journal › Letter › peer-review

3 Scopus citations

Abstract

To the Editor: Several omissions in the letter by Roach and Carlin (Oct. 21 issue)¹ should be noted. First of all, the claim that N,N-dimethylglycine (DMG) is “a normal body constituent” omits the fact that it is only transiently present, and in quantities too small to measure easily.²^,³ Omitting this fact conveys the erroneous impression that the large “healthfood”-size doses (20 to 50 mg of synthetic DMG and hydrochloric acid three times daily) are safe. Secondly, the report of an alleged reduction in the frequency of seizures after ingestion of DMG (N-methylsarcosine) did not separate cause.

Original language	English
Pages (from-to)	527-528
Number of pages	2
Journal	New England Journal of Medicine
Volume	308
Issue number	9
DOIs	https://doi.org/10.1056/NEJM198303033080919
State	Published - Mar 3 1983

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title = "N,N-Dimethylglycine for Epilepsy",

abstract = "To the Editor: Several omissions in the letter by Roach and Carlin (Oct. 21 issue)1 should be noted. First of all, the claim that N,N-dimethylglycine (DMG) is “a normal body constituent” omits the fact that it is only transiently present, and in quantities too small to measure easily.2,3 Omitting this fact conveys the erroneous impression that the large “healthfood”-size doses (20 to 50 mg of synthetic DMG and hydrochloric acid three times daily) are safe. Secondly, the report of an alleged reduction in the frequency of seizures after ingestion of DMG (N-methylsarcosine) did not separate cause.",

author = "Victor Herbert and Roach, \{E. Steve\} and Lane Carlin",

year = "1983",

month = mar,

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doi = "10.1056/NEJM198303033080919",

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TY - JOUR

T1 - N,N-Dimethylglycine for Epilepsy

AU - Herbert, Victor

AU - Roach, E. Steve

AU - Carlin, Lane

PY - 1983/3/3

Y1 - 1983/3/3

N2 - To the Editor: Several omissions in the letter by Roach and Carlin (Oct. 21 issue)1 should be noted. First of all, the claim that N,N-dimethylglycine (DMG) is “a normal body constituent” omits the fact that it is only transiently present, and in quantities too small to measure easily.2,3 Omitting this fact conveys the erroneous impression that the large “healthfood”-size doses (20 to 50 mg of synthetic DMG and hydrochloric acid three times daily) are safe. Secondly, the report of an alleged reduction in the frequency of seizures after ingestion of DMG (N-methylsarcosine) did not separate cause.

AB - To the Editor: Several omissions in the letter by Roach and Carlin (Oct. 21 issue)1 should be noted. First of all, the claim that N,N-dimethylglycine (DMG) is “a normal body constituent” omits the fact that it is only transiently present, and in quantities too small to measure easily.2,3 Omitting this fact conveys the erroneous impression that the large “healthfood”-size doses (20 to 50 mg of synthetic DMG and hydrochloric acid three times daily) are safe. Secondly, the report of an alleged reduction in the frequency of seizures after ingestion of DMG (N-methylsarcosine) did not separate cause.

UR - https://www.scopus.com/pages/publications/0020683054

U2 - 10.1056/NEJM198303033080919

DO - 10.1056/NEJM198303033080919

M3 - Letter

C2 - 6185843

AN - SCOPUS:0020683054

SN - 0028-4793

VL - 308

SP - 527

EP - 528

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 9

ER -

N,N-Dimethylglycine for Epilepsy

Abstract

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