Novel clonal der(9)t(5;9)(q31;q34) cytogenetic translocation in a giant cell tumor of bone

Neetha Santosh; Nyla A. Heerema; Joel L. Mayerson; Obiajulu H. Iwenofu

doi:10.1097/PAI.0000000000000281

Novel clonal der(9)t(5;9)(q31;q34) cytogenetic translocation in a giant cell tumor of bone

Neetha Santosh
, Nyla A. Heerema
, Joel L. Mayerson
, Obiajulu H. Iwenofu

Research output: Contribution to journal › Article › peer-review

Abstract

Giant cell tumor of the bone (GCTB) is a benign but locally aggressive neoplasm of long bones with higher chances of local recurrence. Many cytogenetic studies have reported clonal telomeric associations with GCTB. Here, we report for the first time a novel clonal translocation, der(9)t(5;9)(q31;q34), in a 25-year-old male patient with GCTB in the left distal femur. The biological significance of this translocation remains to be determined.

Original language	English
Pages (from-to)	e17-e21
Journal	Applied Immunohistochemistry and Molecular Morphology
Volume	23
Issue number	10
DOIs	https://doi.org/10.1097/PAI.0000000000000281
State	Published - Jan 1 2015

Keywords

Chromosomal abnormalities
Clonal translocation
Giant cell tumor of bone

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10.1097/PAI.0000000000000281

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abstract = "Giant cell tumor of the bone (GCTB) is a benign but locally aggressive neoplasm of long bones with higher chances of local recurrence. Many cytogenetic studies have reported clonal telomeric associations with GCTB. Here, we report for the first time a novel clonal translocation, der(9)t(5;9)(q31;q34), in a 25-year-old male patient with GCTB in the left distal femur. The biological significance of this translocation remains to be determined.",

keywords = "Chromosomal abnormalities, Clonal translocation, Giant cell tumor of bone",

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AU - Santosh, Neetha

AU - Heerema, Nyla A.

AU - Mayerson, Joel L.

AU - Iwenofu, Obiajulu H.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Giant cell tumor of the bone (GCTB) is a benign but locally aggressive neoplasm of long bones with higher chances of local recurrence. Many cytogenetic studies have reported clonal telomeric associations with GCTB. Here, we report for the first time a novel clonal translocation, der(9)t(5;9)(q31;q34), in a 25-year-old male patient with GCTB in the left distal femur. The biological significance of this translocation remains to be determined.

AB - Giant cell tumor of the bone (GCTB) is a benign but locally aggressive neoplasm of long bones with higher chances of local recurrence. Many cytogenetic studies have reported clonal telomeric associations with GCTB. Here, we report for the first time a novel clonal translocation, der(9)t(5;9)(q31;q34), in a 25-year-old male patient with GCTB in the left distal femur. The biological significance of this translocation remains to be determined.

KW - Chromosomal abnormalities

KW - Clonal translocation

KW - Giant cell tumor of bone

UR - https://www.scopus.com/pages/publications/84947209199

U2 - 10.1097/PAI.0000000000000281

DO - 10.1097/PAI.0000000000000281

M3 - Article

C2 - 26551341

AN - SCOPUS:84947209199

SN - 1541-2016

VL - 23

SP - e17-e21

JO - Applied Immunohistochemistry and Molecular Morphology

JF - Applied Immunohistochemistry and Molecular Morphology

IS - 10

ER -

Novel clonal der(9)t(5;9)(q31;q34) cytogenetic translocation in a giant cell tumor of bone

Abstract

Keywords

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