@article{b58372c59a6446549626df9c6b5dd17a,
title = "O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3",
abstract = "The role of individual glucose metabolic pathways in innate immunity remains largely unknown. Li et al. demonstrate that attenuated O-linked β-N-acetylglucosamine (O-GlcNAc) signaling enhances TLR-induced innate immune response and necroptosis. Mechanistically, O-GlcNAcylation of the kinase RIPK3 blocks RHIM-domain-mediated protein interaction and downstream signaling activation.",
keywords = "HBP, O-GlcNAc, OGT, RIPK3, inflammation, necroptosis",
author = "Xinghui Li and Wei Gong and Hao Wang and Tianliang Li and Attri, {Kuldeep S.} and Lewis, {Robert E.} and Kalil, {Andre C.} and Fatema Bhinderwala and Robert Powers and Guowei Yin and Herring, {Laura E.} and Asara, {John M.} and Lei, {Yu L.} and Xiaoyong Yang and Rodriguez, {Diego A.} and Mao Yang and Green, {Douglas R.} and Singh, {Pankaj K.} and Haitao Wen",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",
year = "2019",
month = mar,
day = "19",
doi = "10.1016/j.immuni.2019.01.007",
language = "English",
volume = "50",
pages = "576--590.e6",
journal = "Immunity",
issn = "1074-7613",
number = "3",
}