Pathways of tau fibrillization

Jeff Kuret; Carmen N. Chirita; Erin E. Congdon; Theresa Kannanayakal; Guibin Li; Mihaela Necula; Haishan Yin; Qi Zhong

doi:10.1016/j.bbadis.2004.06.016

Pathways of tau fibrillization

Jeff Kuret
, Carmen N. Chirita
, Erin E. Congdon
, Theresa Kannanayakal
, Guibin Li
, Mihaela Necula
, Haishan Yin
, Qi Zhong

Research output: Contribution to journal › Review article › peer-review

122 Scopus citations

Abstract

New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed.

Original language	English
Pages (from-to)	167-178
Number of pages	12
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1739
Issue number	2
DOIs	https://doi.org/10.1016/j.bbadis.2004.06.016
State	Published - Jan 3 2005

Keywords

Aggregation
Alzheimer's disease
Folding intermediate
Kinetics
Neurofibrillary tangle
Tau

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10.1016/j.bbadis.2004.06.016

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@article{7f1de1bc9ee247f6b3ce00854750366f,

title = "Pathways of tau fibrillization",

abstract = "New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed.",

keywords = "Aggregation, Alzheimer's disease, Folding intermediate, Kinetics, Neurofibrillary tangle, Tau",

author = "Jeff Kuret and Chirita, \{Carmen N.\} and Congdon, \{Erin E.\} and Theresa Kannanayakal and Guibin Li and Mihaela Necula and Haishan Yin and Qi Zhong",

note = "Funding Information: This work was supported by a grant from the National Institute of Health (AG14452).",

year = "2005",

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doi = "10.1016/j.bbadis.2004.06.016",

language = "English",

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T1 - Pathways of tau fibrillization

AU - Kuret, Jeff

AU - Chirita, Carmen N.

AU - Congdon, Erin E.

AU - Kannanayakal, Theresa

AU - Li, Guibin

AU - Necula, Mihaela

AU - Yin, Haishan

AU - Zhong, Qi

N1 - Funding Information: This work was supported by a grant from the National Institute of Health (AG14452).

PY - 2005/1/3

Y1 - 2005/1/3

N2 - New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed.

AB - New methods for analyzing tau fibrillization have yielded insights into the biochemical transitions involved in the process. Here we review the parallels between the sequential progression of tau fibrillization observed macroscopically in Alzheimer's disease (AD) lesions and the pathway of tau aggregation observed in vitro with purified tau preparations. In addition, pharmacological agents for further dissection of fibrillization mechanism and lesion formation are discussed.

KW - Aggregation

KW - Alzheimer's disease

KW - Folding intermediate

KW - Kinetics

KW - Neurofibrillary tangle

KW - Tau

UR - https://www.scopus.com/pages/publications/10944273984

U2 - 10.1016/j.bbadis.2004.06.016

DO - 10.1016/j.bbadis.2004.06.016

M3 - Review article

C2 - 15615636

AN - SCOPUS:10944273984

SN - 0925-4439

VL - 1739

SP - 167

EP - 178

JO - Biochimica et Biophysica Acta - Molecular Basis of Disease

JF - Biochimica et Biophysica Acta - Molecular Basis of Disease

IS - 2

ER -

Pathways of tau fibrillization

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Keywords

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