Prevention of ventricular fibrillation with magnesium sulfate

George E. Billman; Richard S. Hoskins

doi:10.1016/0014-2999(88)90269-5

Prevention of ventricular fibrillation with magnesium sulfate

George E. Billman
, Richard S. Hoskins

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Mongrel dogs with healed myocardial infarctions were given a 2 min coronary occlusion during an exercise test. The exercise plus ischemia test induced ventricular fibrillation in nine animals. One week later, the test was repeated after pretreatment with magnesium sulfate (100 mg/kg i.v.). Magnesium prevented ventricular fibrillation in seven of the nine animals without adverse side effects. Thus, magnesium may be useful in the management of ventricular fibrillation during ischemia.

Original language	English
Pages (from-to)	167-171
Number of pages	5
Journal	European Journal of Pharmacology
Volume	158
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(88)90269-5
State	Published - Dec 6 1988

Keywords

Ca channel antagonists
Cardiac arrhythmia
Cardiac death (sudden)
Mg
Ventricular fibrillation

Access to Document

10.1016/0014-2999(88)90269-5

Cite this

@article{cfee787adcd94c7ba058e315ce33ef56,

title = "Prevention of ventricular fibrillation with magnesium sulfate",

abstract = "Mongrel dogs with healed myocardial infarctions were given a 2 min coronary occlusion during an exercise test. The exercise plus ischemia test induced ventricular fibrillation in nine animals. One week later, the test was repeated after pretreatment with magnesium sulfate (100 mg/kg i.v.). Magnesium prevented ventricular fibrillation in seven of the nine animals without adverse side effects. Thus, magnesium may be useful in the management of ventricular fibrillation during ischemia.",

keywords = "Ca channel antagonists, Cardiac arrhythmia, Cardiac death (sudden), Mg, Ventricular fibrillation",

author = "Billman, \{George E.\} and Hoskins, \{Richard S.\}",

year = "1988",

month = dec,

day = "6",

doi = "10.1016/0014-2999(88)90269-5",

language = "English",

volume = "158",

pages = "167--171",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

number = "1-2",

}

TY - JOUR

T1 - Prevention of ventricular fibrillation with magnesium sulfate

AU - Billman, George E.

AU - Hoskins, Richard S.

PY - 1988/12/6

Y1 - 1988/12/6

N2 - Mongrel dogs with healed myocardial infarctions were given a 2 min coronary occlusion during an exercise test. The exercise plus ischemia test induced ventricular fibrillation in nine animals. One week later, the test was repeated after pretreatment with magnesium sulfate (100 mg/kg i.v.). Magnesium prevented ventricular fibrillation in seven of the nine animals without adverse side effects. Thus, magnesium may be useful in the management of ventricular fibrillation during ischemia.

AB - Mongrel dogs with healed myocardial infarctions were given a 2 min coronary occlusion during an exercise test. The exercise plus ischemia test induced ventricular fibrillation in nine animals. One week later, the test was repeated after pretreatment with magnesium sulfate (100 mg/kg i.v.). Magnesium prevented ventricular fibrillation in seven of the nine animals without adverse side effects. Thus, magnesium may be useful in the management of ventricular fibrillation during ischemia.

KW - Ca channel antagonists

KW - Cardiac arrhythmia

KW - Cardiac death (sudden)

KW - Mg

KW - Ventricular fibrillation

UR - https://www.scopus.com/pages/publications/0024270971

U2 - 10.1016/0014-2999(88)90269-5

DO - 10.1016/0014-2999(88)90269-5

M3 - Article

C2 - 3220116

AN - SCOPUS:0024270971

SN - 0014-2999

VL - 158

SP - 167

EP - 171

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-2

ER -

Prevention of ventricular fibrillation with magnesium sulfate

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this