PTX cruiser: Driving autoimmunity via TLR4

Michael K. Racke; Wei Hu; Amy E. Lovett-Racke

doi:10.1016/j.it.2005.03.012

PTX cruiser: Driving autoimmunity via TLR4

Michael K. Racke
, Wei Hu
, Amy E. Lovett-Racke

Research output: Contribution to journal › Short survey › peer-review

66 Scopus citations

Abstract

Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.

Original language	English
Pages (from-to)	289-291
Number of pages	3
Journal	Trends in Immunology
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.it.2005.03.012
State	Published - Jun 2005

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title = "PTX cruiser: Driving autoimmunity via TLR4",

abstract = "Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.",

author = "Racke, \{Michael K.\} and Wei Hu and Lovett-Racke, \{Amy E.\}",

note = "Funding Information: Supported by grants from the National Institutes of Health (MKR) and National Multiple Sclerosis Society (MKR, AELR). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2005",

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T2 - Driving autoimmunity via TLR4

AU - Racke, Michael K.

AU - Hu, Wei

AU - Lovett-Racke, Amy E.

N1 - Funding Information: Supported by grants from the National Institutes of Health (MKR) and National Multiple Sclerosis Society (MKR, AELR). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2005/6

Y1 - 2005/6

N2 - Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.

AB - Although the cause of autoimmune diseases is unknown, it has long been speculated that an infectious agent might have a role in their initiation and progression. Experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), has been used to study factors in disease pathogenesis. A recent study shows that pertussis toxin, which is used as an adjuvant in EAE, uses Toll-like receptor 4 signaling to mediate its disease-inducing effect.

UR - https://www.scopus.com/pages/publications/19544363581

U2 - 10.1016/j.it.2005.03.012

DO - 10.1016/j.it.2005.03.012

M3 - Short survey

C2 - 15922942

AN - SCOPUS:19544363581

SN - 1471-4906

VL - 26

SP - 289

EP - 291

JO - Trends in Immunology

JF - Trends in Immunology

IS - 6

ER -

PTX cruiser: Driving autoimmunity via TLR4

Abstract

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