Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity

Melanie A. Krook; Hui Zi Chen; Russell Bonneville; Patricia Allenby; Sameek Roychowdhury

doi:10.1016/j.trecan.2018.11.004

Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity

Melanie A. Krook
, Hui Zi Chen
, Russell Bonneville
, Patricia Allenby
, Sameek Roychowdhury

Research output: Contribution to journal › Short survey › peer-review

11 Scopus citations

Abstract

Tumor heterogeneity decreases the effectiveness of anticancer therapies and is an important topic in translational cancer research, given its relevance in clinical oncology. Here, we discuss how rapid research autopsy of cancer patients can elucidate heterogeneity-associated processes including cancer evolution and acquired therapeutic resistance. In practice, rapid research autopsy is performed shortly after a patient's passing to procure multiple metastatic tumor samples for genomic studies through next-generation sequencing and development of patient-derived xenografts or organoids. Mechanistic insights gained from research autopsy studies of cancer patients can help identify new targets for therapeutic intervention. Finally, the success of research autopsy programs is bolstered by collaboration across different medical and scientific disciplines in addition to support from patients and families.

Original language	English
Pages (from-to)	1-5
Number of pages	5
Journal	Trends in Cancer
Volume	5
Issue number	1
DOIs	https://doi.org/10.1016/j.trecan.2018.11.004
State	Published - Jan 2019

Keywords

rapid research autopsy
translational cancer research
tumor heterogeneity

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10.1016/j.trecan.2018.11.004

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title = "Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity",

abstract = "Tumor heterogeneity decreases the effectiveness of anticancer therapies and is an important topic in translational cancer research, given its relevance in clinical oncology. Here, we discuss how rapid research autopsy of cancer patients can elucidate heterogeneity-associated processes including cancer evolution and acquired therapeutic resistance. In practice, rapid research autopsy is performed shortly after a patient's passing to procure multiple metastatic tumor samples for genomic studies through next-generation sequencing and development of patient-derived xenografts or organoids. Mechanistic insights gained from research autopsy studies of cancer patients can help identify new targets for therapeutic intervention. Finally, the success of research autopsy programs is bolstered by collaboration across different medical and scientific disciplines in addition to support from patients and families.",

keywords = "rapid research autopsy, translational cancer research, tumor heterogeneity",

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T2 - Piecing the Puzzle of Tumor Heterogeneity

AU - Krook, Melanie A.

AU - Chen, Hui Zi

AU - Bonneville, Russell

AU - Allenby, Patricia

AU - Roychowdhury, Sameek

PY - 2019/1

Y1 - 2019/1

N2 - Tumor heterogeneity decreases the effectiveness of anticancer therapies and is an important topic in translational cancer research, given its relevance in clinical oncology. Here, we discuss how rapid research autopsy of cancer patients can elucidate heterogeneity-associated processes including cancer evolution and acquired therapeutic resistance. In practice, rapid research autopsy is performed shortly after a patient's passing to procure multiple metastatic tumor samples for genomic studies through next-generation sequencing and development of patient-derived xenografts or organoids. Mechanistic insights gained from research autopsy studies of cancer patients can help identify new targets for therapeutic intervention. Finally, the success of research autopsy programs is bolstered by collaboration across different medical and scientific disciplines in addition to support from patients and families.

AB - Tumor heterogeneity decreases the effectiveness of anticancer therapies and is an important topic in translational cancer research, given its relevance in clinical oncology. Here, we discuss how rapid research autopsy of cancer patients can elucidate heterogeneity-associated processes including cancer evolution and acquired therapeutic resistance. In practice, rapid research autopsy is performed shortly after a patient's passing to procure multiple metastatic tumor samples for genomic studies through next-generation sequencing and development of patient-derived xenografts or organoids. Mechanistic insights gained from research autopsy studies of cancer patients can help identify new targets for therapeutic intervention. Finally, the success of research autopsy programs is bolstered by collaboration across different medical and scientific disciplines in addition to support from patients and families.

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M3 - Short survey

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SN - 2405-8033

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SP - 1

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ER -

Rapid Research Autopsy: Piecing the Puzzle of Tumor Heterogeneity

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Keywords

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