Review of S100A9 biology and its role in cancer

Joseph Markowitz; William E. Carson

doi:10.1016/j.bbcan.2012.10.003

Review of S100A9 biology and its role in cancer

Joseph Markowitz, William E. Carson

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

S100A9 is a calcium binding protein with multiple ligands and post-translation modifications that is involved in inflammatory events and the initial development of the cancer cell through to the development of metastatic disease. This review has a threefold purpose: 1) describe the S100A9 structural elements important for its biological activity, 2) describe the S100A9 biology in the context of the immune system, and 3) illustrate the role of S100A9 in the development of malignancy via interactions with the immune system and other cellular processes.

Original language	English
Pages (from-to)	100-109
Number of pages	10
Journal	Biochimica et Biophysica Acta - Reviews on Cancer
Volume	1835
Issue number	1
DOIs	https://doi.org/10.1016/j.bbcan.2012.10.003
State	Published - Jan 2013

Keywords

Calgranulin B
Cancer
MRP-14
S100A9

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10.1016/j.bbcan.2012.10.003

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title = "Review of S100A9 biology and its role in cancer",

abstract = "S100A9 is a calcium binding protein with multiple ligands and post-translation modifications that is involved in inflammatory events and the initial development of the cancer cell through to the development of metastatic disease. This review has a threefold purpose: 1) describe the S100A9 structural elements important for its biological activity, 2) describe the S100A9 biology in the context of the immune system, and 3) illustrate the role of S100A9 in the development of malignancy via interactions with the immune system and other cellular processes.",

keywords = "Calgranulin B, Cancer, MRP-14, S100A9",

author = "Joseph Markowitz and Carson, {William E.}",

note = "Funding Information: This review was supported by T32CA090223 (to J. Markowitz). Funding Information: Molecular graphics images were produced using the UCSF Chimera package from the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco (supported by NIH P41 RR001081 ).",

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AU - Carson, William E.

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AB - S100A9 is a calcium binding protein with multiple ligands and post-translation modifications that is involved in inflammatory events and the initial development of the cancer cell through to the development of metastatic disease. This review has a threefold purpose: 1) describe the S100A9 structural elements important for its biological activity, 2) describe the S100A9 biology in the context of the immune system, and 3) illustrate the role of S100A9 in the development of malignancy via interactions with the immune system and other cellular processes.

KW - Calgranulin B

KW - Cancer

KW - MRP-14

KW - S100A9

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Review of S100A9 biology and its role in cancer

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Keywords

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