Roles of Androgen Receptor Signaling in Urothelial Carcinoma

Debasish Sundi; Katharine A. Collier; Yuanquan Yang; Dayssy Alexandra Diaz; Kamal S. Pohar; Eric A. Singer; Sanjay Gupta; William E. Carson; Steven K. Clinton; Zihai Li; Edward M. Messing

doi:10.3390/cancers16040746

Roles of Androgen Receptor Signaling in Urothelial Carcinoma

Debasish Sundi, Katharine A. Collier, Yuanquan Yang, Dayssy Alexandra Diaz, Kamal S. Pohar, Eric A. Singer, Sanjay Gupta, William E. Carson, Steven K. Clinton, Zihai Li, Edward M. Messing

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.

Original language	English
Article number	746
Journal	Cancers
Volume	16
Issue number	4
DOIs	https://doi.org/10.3390/cancers16040746
State	Published - Feb 2024

Keywords

androgen receptor
anti-tumor immunity
bladder cancer

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10.3390/cancers16040746

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title = "Roles of Androgen Receptor Signaling in Urothelial Carcinoma",

abstract = "Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.",

keywords = "androgen receptor, anti-tumor immunity, bladder cancer",

author = "Debasish Sundi and Collier, {Katharine A.} and Yuanquan Yang and Diaz, {Dayssy Alexandra} and Pohar, {Kamal S.} and Singer, {Eric A.} and Sanjay Gupta and Carson, {William E.} and Clinton, {Steven K.} and Zihai Li and Messing, {Edward M.}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

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doi = "10.3390/cancers16040746",

language = "English",

volume = "16",

journal = "Cancers",

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TY - JOUR

T1 - Roles of Androgen Receptor Signaling in Urothelial Carcinoma

AU - Sundi, Debasish

AU - Collier, Katharine A.

AU - Yang, Yuanquan

AU - Diaz, Dayssy Alexandra

AU - Pohar, Kamal S.

AU - Singer, Eric A.

AU - Gupta, Sanjay

AU - Carson, William E.

AU - Clinton, Steven K.

AU - Li, Zihai

AU - Messing, Edward M.

PY - 2024/2

Y1 - 2024/2

N2 - Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.

AB - Preclinical and clinical data suggest that androgen receptor signaling strongly contributes to bladder cancer development. The roles of the androgen receptor in bladder carcinogenesis have obvious implications for understanding the strong male sex bias in this disease and for potential therapeutic strategies as well. In this review, we summarize what is known about androgen receptor signaling in urothelial carcinoma as well as in tumor-infiltrating immune cells, reviewing preclinical and clinical data. We also highlight clinical trial efforts in this area.

KW - androgen receptor

KW - anti-tumor immunity

KW - bladder cancer

UR - http://www.scopus.com/inward/record.url?scp=85185924984&partnerID=8YFLogxK

U2 - 10.3390/cancers16040746

DO - 10.3390/cancers16040746

M3 - Review article

AN - SCOPUS:85185924984

SN - 2072-6694

VL - 16

JO - Cancers

JF - Cancers

IS - 4

M1 - 746

ER -

Roles of Androgen Receptor Signaling in Urothelial Carcinoma

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