TY - JOUR
T1 - Sex Differences in Early Weight Loss Success during a Diabetes Prevention Intervention
AU - Miller, Carla K.
AU - Nagaraja, Haikady N.
AU - Cheavens, Jennifer S.
AU - Fujita, Kentaro
AU - Lazarus, Sophie A.
AU - Brunette, Daniel S.
N1 - Funding Information:
The National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health supported this research under award number R01DK112930 and by award number UL1TR002733 from the National Center for Advancing Translational Sciences. The content is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Advancing Translational Sciences or the National Institutes of Health (Clinical Trial Registration Number: NCT03382873, clinicaltrials. gov). The authors are grateful for the time and support provided by study participants.
Publisher Copyright:
© 2023 PNG Publications. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Objectives: Males often lose more weight than females during treatment, and early weight loss predicts weight loss longer-term. Yet, mechanisms for sex differences in early weight loss are unknown and were examined in this study. Methods: Adults≥21 years old with overweight or obesity and prediabetes (N=206) participated in a lifestyle intervention and completed baseline psychosocial questionnaires. Percent weight loss, session attendance, and number of days participants self-monitored dietary intake and weight were determined at week 5. Principal components, regression, and mediation analyses were conducted to determine whether weight loss differed by sex and potential mediators of weight change. Results: Mean (±SD) weight loss was greater for males (2.59±1.62%) than females (2.05±1.54%; p=.02). Attendance, self-monitoring, and beliefs regarding disease risk were independent predictors of weight loss (all p<.05) but did not explain sex differences. The association between attendance and weight loss was stronger for males than females (p<.05). Conclusions: Additional research is needed to identify mechanisms that explain sex differences in early weight loss. However, strengthening risk beliefs, attendance, and self-monitoring may promote greater early weight loss for all participants.
AB - Objectives: Males often lose more weight than females during treatment, and early weight loss predicts weight loss longer-term. Yet, mechanisms for sex differences in early weight loss are unknown and were examined in this study. Methods: Adults≥21 years old with overweight or obesity and prediabetes (N=206) participated in a lifestyle intervention and completed baseline psychosocial questionnaires. Percent weight loss, session attendance, and number of days participants self-monitored dietary intake and weight were determined at week 5. Principal components, regression, and mediation analyses were conducted to determine whether weight loss differed by sex and potential mediators of weight change. Results: Mean (±SD) weight loss was greater for males (2.59±1.62%) than females (2.05±1.54%; p=.02). Attendance, self-monitoring, and beliefs regarding disease risk were independent predictors of weight loss (all p<.05) but did not explain sex differences. The association between attendance and weight loss was stronger for males than females (p<.05). Conclusions: Additional research is needed to identify mechanisms that explain sex differences in early weight loss. However, strengthening risk beliefs, attendance, and self-monitoring may promote greater early weight loss for all participants.
KW - lifestyle risk reduction
KW - mediation analysis
KW - obesity
KW - prediabetes
KW - weight loss
UR - https://www.scopus.com/pages/publications/85160145977
U2 - 10.5993/AJHB.47.2.13
DO - 10.5993/AJHB.47.2.13
M3 - Article
C2 - 37226352
AN - SCOPUS:85160145977
SN - 1087-3244
VL - 47
SP - 337
EP - 348
JO - American Journal of Health Behavior
JF - American Journal of Health Behavior
IS - 2
ER -