Targeting deubiquitinases in CLL

Deepa Sampath

doi:10.1182/blood-2017-06-786236

Targeting deubiquitinases in CLL

Deepa Sampath

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.¹

Original language	English
Pages (from-to)	100-101
Number of pages	2
Journal	Blood
Volume	130
Issue number	2
DOIs	https://doi.org/10.1182/blood-2017-06-786236
State	Published - Jul 13 2017

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title = "Targeting deubiquitinases in CLL",

abstract = "In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.1",

author = "Deepa Sampath",

note = "Publisher Copyright: {\textcopyright} 2017 by The American Society of Hematology.",

year = "2017",

month = jul,

day = "13",

doi = "10.1182/blood-2017-06-786236",

language = "English",

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T1 - Targeting deubiquitinases in CLL

AU - Sampath, Deepa

PY - 2017/7/13

Y1 - 2017/7/13

N2 - In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.1

AB - In this issue of Blood, Agathanggelou et al demonstrate that inhibition of ubiquitin-specific protease 7 (USP7) compromises homologous recombination DNA repair in part by destabilizing the E3 ligase RAD18 leading to the accumulation of DNA damage which kills chronic lymphocytic leukemia (CLL) cells independently of ataxia telangiectasia mutated (ATM) and p53.1

UR - https://www.scopus.com/pages/publications/85024116130

U2 - 10.1182/blood-2017-06-786236

DO - 10.1182/blood-2017-06-786236

M3 - Comment/debate

C2 - 28705854

AN - SCOPUS:85024116130

SN - 0006-4971

VL - 130

SP - 100

EP - 101

JO - Blood

JF - Blood

IS - 2

ER -

Targeting deubiquitinases in CLL

Abstract

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