The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation

Timothy K. Eitas; Wei Chun Chou; Haitao Wen; Denis Gris; Gregory R. Robbins; June Brickey; Yoshitaka Oyama; Jenny P.Y. Ting

doi:10.1074/jbc.M113.533034

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation

Timothy K. Eitas, Wei Chun Chou, Haitao Wen, Denis Gris, Gregory R. Robbins, June Brickey, Yoshitaka Oyama, Jenny P.Y. Ting

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in vivo and inhibits microglial (Mg) activation. Conclusion: NLRX1 immunosuppressive function in Mg correlates with suppression of neuroinflammation during mouse models of Multiple Sclerosis (MS). Significance: NLR genes can have protective roles during neuroinflammation.

Original language	English
Pages (from-to)	4173-4179
Number of pages	7
Journal	Journal of Biological Chemistry
Volume	289
Issue number	7
DOIs	https://doi.org/10.1074/jbc.M113.533034
State	Published - Feb 14 2014

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Eitas, T. K., Chou, W. C., Wen, H., Gris, D., Robbins, G. R., Brickey, J., Oyama, Y., & Ting, J. P. Y. (2014). The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation. Journal of Biological Chemistry, 289(7), 4173-4179. https://doi.org/10.1074/jbc.M113.533034

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title = "The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation",

abstract = "Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in vivo and inhibits microglial (Mg) activation. Conclusion: NLRX1 immunosuppressive function in Mg correlates with suppression of neuroinflammation during mouse models of Multiple Sclerosis (MS). Significance: NLR genes can have protective roles during neuroinflammation.",

author = "Eitas, {Timothy K.} and Chou, {Wei Chun} and Haitao Wen and Denis Gris and Robbins, {Gregory R.} and June Brickey and Yoshitaka Oyama and Ting, {Jenny P.Y.}",

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doi = "10.1074/jbc.M113.533034",

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Eitas, TK, Chou, WC, Wen, H, Gris, D, Robbins, GR, Brickey, J, Oyama, Y & Ting, JPY 2014, 'The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation', Journal of Biological Chemistry, vol. 289, no. 7, pp. 4173-4179. https://doi.org/10.1074/jbc.M113.533034

The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation. / Eitas, Timothy K.; Chou, Wei Chun; Wen, Haitao et al.
In: Journal of Biological Chemistry, Vol. 289, No. 7, 14.02.2014, p. 4173-4179.

Research output: Contribution to journal › Article › peer-review

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AU - Eitas, Timothy K.

AU - Chou, Wei Chun

AU - Wen, Haitao

AU - Gris, Denis

AU - Robbins, Gregory R.

AU - Brickey, June

AU - Oyama, Yoshitaka

AU - Ting, Jenny P.Y.

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N2 - Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in vivo and inhibits microglial (Mg) activation. Conclusion: NLRX1 immunosuppressive function in Mg correlates with suppression of neuroinflammation during mouse models of Multiple Sclerosis (MS). Significance: NLR genes can have protective roles during neuroinflammation.

AB - Background: The nucleotide-binding leucine-rich repeat (NLR) family of innate immune genes are important regulators of inflammatory responses in mammals. Results: The NLR gene, Nlrx1, suppresses neuroinflammation in vivo and inhibits microglial (Mg) activation. Conclusion: NLRX1 immunosuppressive function in Mg correlates with suppression of neuroinflammation during mouse models of Multiple Sclerosis (MS). Significance: NLR genes can have protective roles during neuroinflammation.

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The nucleotide-binding leucine-rich repeat (NLR) family member NLRX1 mediates protection against experimental autoimmune encephalomyelitis and represses macrophage/ microglia-induced inflammation

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