The Rationale and Timing of Molecular Genetic Testing for Dilated Cardiomyopathy

Ana Morales; Ray E. Hershberger

doi:10.1016/j.cjca.2015.06.034

The Rationale and Timing of Molecular Genetic Testing for Dilated Cardiomyopathy

Ana Morales
, Ray E. Hershberger

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The genetic evaluation of dilated cardiomyopathy (DCM) has been challenging, owing in large part to marked genetic heterogeneity. However, lower costs from next-generation sequencing have enabled gene discovery and the expansion of genetic testing panels. These advances have improved molecular diagnostics and predictive testing in DCM. We provide a rationale and recommendation for clinical genetic testing in all DCM cases.

Original language	English
Pages (from-to)	1309-1312
Number of pages	4
Journal	Canadian Journal of Cardiology
Volume	31
Issue number	11
DOIs	https://doi.org/10.1016/j.cjca.2015.06.034
State	Published - Nov 2015

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abstract = "The genetic evaluation of dilated cardiomyopathy (DCM) has been challenging, owing in large part to marked genetic heterogeneity. However, lower costs from next-generation sequencing have enabled gene discovery and the expansion of genetic testing panels. These advances have improved molecular diagnostics and predictive testing in DCM. We provide a rationale and recommendation for clinical genetic testing in all DCM cases.",

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AB - The genetic evaluation of dilated cardiomyopathy (DCM) has been challenging, owing in large part to marked genetic heterogeneity. However, lower costs from next-generation sequencing have enabled gene discovery and the expansion of genetic testing panels. These advances have improved molecular diagnostics and predictive testing in DCM. We provide a rationale and recommendation for clinical genetic testing in all DCM cases.

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The Rationale and Timing of Molecular Genetic Testing for Dilated Cardiomyopathy

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