Abstract
Transcription of latent Epstein-Barr virus genomes in somatic cell hybrids of Burkitt lymphoblastoid cells has been studied. D98/HR-1, D98/Raji, and Raji cells contained viral RNA transcribed from approximately 25% of virus DNA. After iododeoxyuridine (IUdR) induction 50% of virus DNA was found transcribed in these three cell lines. Raji cells, however, showed production of early antigens (EA) only, whereas the two other cell lines produced both EA and virus capsid antigens, suggesting that there may be some post-transcriptional control in Roji cells after IUdR induction. The amount of virus RNA in the cells calculated from DNA-RNA hybridization kinetics was proportional to the number of virus genomes per cell. This suggests that a constant fraction of the multiple copies of virus DNA is transcribed in the three different cell systems.
| Original language | English |
|---|---|
| Pages (from-to) | 63-68 |
| Number of pages | 6 |
| Journal | Virology |
| Volume | 82 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 1 1977 |
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