Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment

Thilanga N. Pahattuge, J. Matt Jackson, Rane Digamber, Harshani Wijerathne, Virginia Brown, Malgorzata A. Witek, Chamani Perera, Richard S. Givens, Blake R. Peterson, Steven A. Soper

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400-450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.

Original languageEnglish
Pages (from-to)4098-4101
Number of pages4
JournalChemical Communications
Volume56
Issue number29
DOIs
StatePublished - Apr 14 2020

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