TY - JOUR
T1 - A contemporary review of snoRNAs in cardiovascular health
T2 - RNA modification and beyond
AU - Jagielski, Noah Peter
AU - Rai, Amit Kumar
AU - Rajan, K. Shanmugha
AU - Mangal, Vatsal
AU - Garikipati, Venkata Naga Srikanth
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2024/3/12
Y1 - 2024/3/12
N2 - As cardiovascular diseases continue to be the leading cause of death worldwide, groundbreaking research is being conducted to mitigate their effects. This review looks into the potential of small nucleolar RNAs (snoRNAs) and the opportunity to use these molecular agents as therapeutic biomarkers for cardiovascular issues specific to the heart. Through an investigation of snoRNA biogenesis, functionality, and roles in cardiovascular diseases, this review relates our past and present knowledge of snoRNAs to the current scientific literature. Considering the initial discovery of snoRNAs and the studies thereafter analyzing the roles of snoRNAs in disease, we look forward to uncovering many other noncanonical functions that could lead researchers closer to finding preventive and curative solutions for cardiovascular diseases.
AB - As cardiovascular diseases continue to be the leading cause of death worldwide, groundbreaking research is being conducted to mitigate their effects. This review looks into the potential of small nucleolar RNAs (snoRNAs) and the opportunity to use these molecular agents as therapeutic biomarkers for cardiovascular issues specific to the heart. Through an investigation of snoRNA biogenesis, functionality, and roles in cardiovascular diseases, this review relates our past and present knowledge of snoRNAs to the current scientific literature. Considering the initial discovery of snoRNAs and the studies thereafter analyzing the roles of snoRNAs in disease, we look forward to uncovering many other noncanonical functions that could lead researchers closer to finding preventive and curative solutions for cardiovascular diseases.
KW - C/D box snoRNA
KW - H/ACA box snoRNA
KW - MT: Noncoding RNAs
KW - RNA modification
KW - cardiovascular diseases
KW - noncoding RNAs
KW - scaRNA
UR - http://www.scopus.com/inward/record.url?scp=85180081461&partnerID=8YFLogxK
U2 - 10.1016/j.omtn.2023.102087
DO - 10.1016/j.omtn.2023.102087
M3 - Review article
AN - SCOPUS:85180081461
SN - 2162-2531
VL - 35
JO - Molecular Therapy - Nucleic Acids
JF - Molecular Therapy - Nucleic Acids
IS - 1
M1 - 102087
ER -