TY - JOUR
T1 - Adenoid cystic carcinoma metastatic to the kidney
T2 - a series of 10 patients emphasizing unilateral presentation and long time interval from primary diagnosis
AU - Akgul, Mahmut
AU - Cha, Jennifer
AU - Williamson, Sean R.
AU - Arora, Kanika
AU - Celik, Murat
AU - Rooper, Lisa M.
AU - Zynger, Debra L.
AU - Sangoi, Ankur R.
N1 - Publisher Copyright:
© 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2024/1
Y1 - 2024/1
N2 - Adenoid cystic carcinoma (AdCC) metastasis to kidney is rare. We identified 10 patients with metastatic AdCC in multi-institutional collaboration. Core needle biopsy was the most common specimen (n = 6). Patients were predominately female (n = 7) with a median age of 48 years (35–62 years). The most common primary location of the AdCC was head and neck (n = 6, among them parotid gland = 4), followed by lung (n = 2), breast (n = 1), and vulva (n = 1). Median lapse between primary AdCC and renal metastasis was almost 13 years (154 months, range 1–336 months). Moreover, all but one patient had unilateral kidney metastasis. The majority of metastatic AdCC within the kidney demonstrated mixed growth patterns, frequently cribriform, and tubular morphology. Follow-up available for 8 patients showed 6 alive with disease and 2 died of disease (the longest survival was 4 years past the diagnosis of renal metastasis). A systematic literature review including 29 patients revealed that kidney metastasis by AdCC is usually a late event, is typically unilateral, and is usually composed of one to three foci, and thus has clinical features which mimic a primary renal tumor.
AB - Adenoid cystic carcinoma (AdCC) metastasis to kidney is rare. We identified 10 patients with metastatic AdCC in multi-institutional collaboration. Core needle biopsy was the most common specimen (n = 6). Patients were predominately female (n = 7) with a median age of 48 years (35–62 years). The most common primary location of the AdCC was head and neck (n = 6, among them parotid gland = 4), followed by lung (n = 2), breast (n = 1), and vulva (n = 1). Median lapse between primary AdCC and renal metastasis was almost 13 years (154 months, range 1–336 months). Moreover, all but one patient had unilateral kidney metastasis. The majority of metastatic AdCC within the kidney demonstrated mixed growth patterns, frequently cribriform, and tubular morphology. Follow-up available for 8 patients showed 6 alive with disease and 2 died of disease (the longest survival was 4 years past the diagnosis of renal metastasis). A systematic literature review including 29 patients revealed that kidney metastasis by AdCC is usually a late event, is typically unilateral, and is usually composed of one to three foci, and thus has clinical features which mimic a primary renal tumor.
KW - Adenoid cystic carcinoma
KW - Kidney
KW - Metastasis
UR - http://www.scopus.com/inward/record.url?scp=85177214009&partnerID=8YFLogxK
U2 - 10.1007/s00428-023-03711-6
DO - 10.1007/s00428-023-03711-6
M3 - Article
C2 - 37987868
AN - SCOPUS:85177214009
SN - 0945-6317
VL - 484
SP - 127
EP - 133
JO - Virchows Archiv
JF - Virchows Archiv
IS - 1
ER -