Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

Xiyan Liao; Qin Zeng; Limin Xie; Haowei Zhang; Wanyu Hu; Liuling Xiao; Hui Zhou; Fanqi Wang; Wanqin Xie; Jianfeng Song; Xiaoxiao Sun; Dandan Wang; Yujin Ding; Yayi Jiao; Wuqian Mai; Wufuer Aini; Xiaoyan Hui; Wei Liu; Willa A. Hsueh; Tuo Deng

doi:10.1016/j.celrep.2024.113963

Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

Xiyan Liao, Qin Zeng, Limin Xie, Haowei Zhang, Wanyu Hu, Liuling Xiao, Hui Zhou, Fanqi Wang, Wanqin Xie, Jianfeng Song, Xiaoxiao Sun, Dandan Wang, Yujin Ding, Yayi Jiao, Wuqian Mai, Wufuer Aini, Xiaoyan Hui, Wei Liu, Willa A. Hsueh, Tuo Deng

Research output: Contribution to journal › Article › peer-review

Abstract

T cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as early as 4 weeks of high-fat diet feeding, coinciding with the onset of T cell infiltration into WAT during obesity. ASCs and bone marrow transplantation experiments demonstrate that CCL5 from ASCs plays a crucial role in T cell accumulation during obesity. The production of CCL5 in ASCs is induced by tumor necrosis factor alpha via the nuclear factor κB pathway. Overall, our findings underscore the pivotal role of ASCs in regulating T cell accumulation in WAT during the early phases of obesity, emphasizing their importance in modulating adaptive immunity in obesity-induced adipose inflammation.

Original language	English
Article number	113963
Journal	Cell Reports
Volume	43
Issue number	3
DOIs	https://doi.org/10.1016/j.celrep.2024.113963
State	Published - Mar 26 2024

Keywords

ASCs
CCL5
CP: Metabolism
CP: Stem cell research
T cells
adipose tissue inflammation
obesity

Access to Document

10.1016/j.celrep.2024.113963

Cite this

Liao, X., Zeng, Q., Xie, L., Zhang, H., Hu, W., Xiao, L., Zhou, H., Wang, F., Xie, W., Song, J., Sun, X., Wang, D., Ding, Y., Jiao, Y., Mai, W., Aini, W., Hui, X., Liu, W., Hsueh, W. A., & Deng, T. (2024). Adipose stem cells control obesity-induced T cell infiltration into adipose tissue. Cell Reports, 43(3), Article 113963. https://doi.org/10.1016/j.celrep.2024.113963

@article{d30b9d2c5caa48ae9b8bdb40a795e445,

title = "Adipose stem cells control obesity-induced T cell infiltration into adipose tissue",

abstract = "T cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as early as 4 weeks of high-fat diet feeding, coinciding with the onset of T cell infiltration into WAT during obesity. ASCs and bone marrow transplantation experiments demonstrate that CCL5 from ASCs plays a crucial role in T cell accumulation during obesity. The production of CCL5 in ASCs is induced by tumor necrosis factor alpha via the nuclear factor κB pathway. Overall, our findings underscore the pivotal role of ASCs in regulating T cell accumulation in WAT during the early phases of obesity, emphasizing their importance in modulating adaptive immunity in obesity-induced adipose inflammation.",

keywords = "ASCs, CCL5, CP: Metabolism, CP: Stem cell research, T cells, adipose tissue inflammation, obesity",

author = "Xiyan Liao and Qin Zeng and Limin Xie and Haowei Zhang and Wanyu Hu and Liuling Xiao and Hui Zhou and Fanqi Wang and Wanqin Xie and Jianfeng Song and Xiaoxiao Sun and Dandan Wang and Yujin Ding and Yayi Jiao and Wuqian Mai and Wufuer Aini and Xiaoyan Hui and Wei Liu and Hsueh, {Willa A.} and Tuo Deng",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors",

year = "2024",

month = mar,

day = "26",

doi = "10.1016/j.celrep.2024.113963",

language = "English",

volume = "43",

journal = "Cell Reports",

issn = "2211-1247",

number = "3",

}

TY - JOUR

T1 - Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

AU - Liao, Xiyan

AU - Zeng, Qin

AU - Xie, Limin

AU - Zhang, Haowei

AU - Hu, Wanyu

AU - Xiao, Liuling

AU - Zhou, Hui

AU - Wang, Fanqi

AU - Xie, Wanqin

AU - Song, Jianfeng

AU - Sun, Xiaoxiao

AU - Wang, Dandan

AU - Ding, Yujin

AU - Jiao, Yayi

AU - Mai, Wuqian

AU - Aini, Wufuer

AU - Hui, Xiaoyan

AU - Liu, Wei

AU - Hsueh, Willa A.

AU - Deng, Tuo

PY - 2024/3/26

Y1 - 2024/3/26

N2 - T cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as early as 4 weeks of high-fat diet feeding, coinciding with the onset of T cell infiltration into WAT during obesity. ASCs and bone marrow transplantation experiments demonstrate that CCL5 from ASCs plays a crucial role in T cell accumulation during obesity. The production of CCL5 in ASCs is induced by tumor necrosis factor alpha via the nuclear factor κB pathway. Overall, our findings underscore the pivotal role of ASCs in regulating T cell accumulation in WAT during the early phases of obesity, emphasizing their importance in modulating adaptive immunity in obesity-induced adipose inflammation.

AB - T cell infiltration into white adipose tissue (WAT) drives obesity-induced adipose inflammation, but the mechanisms of obesity-induced T cell infiltration into WAT remain unclear. Our single-cell RNA sequencing reveals a significant impact of adipose stem cells (ASCs) on T cells. Transplanting ASCs from obese mice into WAT enhances T cell accumulation. C-C motif chemokine ligand 5 (CCL5) is upregulated in ASCs as early as 4 weeks of high-fat diet feeding, coinciding with the onset of T cell infiltration into WAT during obesity. ASCs and bone marrow transplantation experiments demonstrate that CCL5 from ASCs plays a crucial role in T cell accumulation during obesity. The production of CCL5 in ASCs is induced by tumor necrosis factor alpha via the nuclear factor κB pathway. Overall, our findings underscore the pivotal role of ASCs in regulating T cell accumulation in WAT during the early phases of obesity, emphasizing their importance in modulating adaptive immunity in obesity-induced adipose inflammation.

KW - ASCs

KW - CCL5

KW - CP: Metabolism

KW - CP: Stem cell research

KW - T cells

KW - adipose tissue inflammation

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85188019683&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2024.113963

DO - 10.1016/j.celrep.2024.113963

M3 - Article

C2 - 38492218

AN - SCOPUS:85188019683

SN - 2211-1247

VL - 43

JO - Cell Reports

JF - Cell Reports

IS - 3

M1 - 113963

ER -

Adipose stem cells control obesity-induced T cell infiltration into adipose tissue

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this