TY - JOUR
T1 - Antibiotic treatment inhibits paclitaxel chemotherapy-induced activity deficits in female mice
AU - Grant, Corena V.
AU - Jordan, Kelley
AU - Seng, Melina M.
AU - Pyter, Leah M.
N1 - Publisher Copyright:
© 2023 Grant et al.
PY - 2023/5
Y1 - 2023/5
N2 - Chemotherapy, a mainstay in the treatment of cancer, is associated with severe and debilitating side effects. Side effects can be physical (e.g., gastrointestinal distress, anemia, and hair loss) or mental (e.g., fatigue, cognitive dysfunction). Chemotherapy is known to alter the gut microbiota; thus, communication through the gut-brain axis may influence behavioral side effects. Here, we used a clinically-relevant paclitaxel chemotherapy regimen in combination with antibiotics to test the hypothesis that gut microbes contribute to chemotherapyassociated fatigue-like behaviors in female mice. Data presented suggest that chemotherapy- altered gut microbes contribute to fatigue-like behaviors in mice by disrupting energy homeostasis.
AB - Chemotherapy, a mainstay in the treatment of cancer, is associated with severe and debilitating side effects. Side effects can be physical (e.g., gastrointestinal distress, anemia, and hair loss) or mental (e.g., fatigue, cognitive dysfunction). Chemotherapy is known to alter the gut microbiota; thus, communication through the gut-brain axis may influence behavioral side effects. Here, we used a clinically-relevant paclitaxel chemotherapy regimen in combination with antibiotics to test the hypothesis that gut microbes contribute to chemotherapyassociated fatigue-like behaviors in female mice. Data presented suggest that chemotherapy- altered gut microbes contribute to fatigue-like behaviors in mice by disrupting energy homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85159597583&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0284365
DO - 10.1371/journal.pone.0284365
M3 - Article
C2 - 37167214
AN - SCOPUS:85159597583
SN - 1932-6203
VL - 18
JO - PLoS ONE
JF - PLoS ONE
IS - 5 May
M1 - e0284365
ER -