TY - JOUR
T1 - Antibody Titers Against Human Cytomegalovirus gM/gN and gB Among Pregnant Women and Their Infants
AU - Talavera-Barber, Maria
AU - Flint, Kaitlyn
AU - Graber, Brianna
AU - Dhital, Ravi
AU - Kaptsan, Irina
AU - Medoro, Alexandra K.
AU - Sánchez, Pablo J.
AU - Shimamura, Masako
N1 - Funding Information:
This study was funded by the National CMV Foundation (MTB) and the Abigail Wexner Research Institute at Nationwide Children's Hospital (MS and PS). The Ohio Pediatric Research Network Pediatric Research Repository (OPRN PRR) was funded by the Abigail Wexner Research Institute at Nationwide Children's Hospital.
Publisher Copyright:
Copyright © 2022 Talavera-Barber, Flint, Graber, Dhital, Kaptsan, Medoro, Sánchez and Shimamura.
PY - 2022/6/23
Y1 - 2022/6/23
N2 - Congenital CMV (cCMV) infection can affect infants born to mothers with preconceptional seroimmunity. To prevent cCMV due to nonprimary maternal infection, vaccines eliciting responses exceeding natural immunity may be required. Anti-gM/gN antibodies have neutralizing capacity in-vitro and in animal models, but anti-gM/gN antibodies have not been characterized among seroimmune pregnant women. Paired maternal and infant cord sera from 92 CMV seropositive mothers and their full-term or preterm infants were tested for anti-gM/gN antibody titers in comparison with anti-gB titers and neutralizing activity. Anti-gM/gN titers were significantly lower than anti-gB titers for all groups and did not correlate with serum neutralizing capacity. Further study is needed to determine if higher anti-gM/gN antibody titers might enhance serum neutralizing capacity among seropositive adults.
AB - Congenital CMV (cCMV) infection can affect infants born to mothers with preconceptional seroimmunity. To prevent cCMV due to nonprimary maternal infection, vaccines eliciting responses exceeding natural immunity may be required. Anti-gM/gN antibodies have neutralizing capacity in-vitro and in animal models, but anti-gM/gN antibodies have not been characterized among seroimmune pregnant women. Paired maternal and infant cord sera from 92 CMV seropositive mothers and their full-term or preterm infants were tested for anti-gM/gN antibody titers in comparison with anti-gB titers and neutralizing activity. Anti-gM/gN titers were significantly lower than anti-gB titers for all groups and did not correlate with serum neutralizing capacity. Further study is needed to determine if higher anti-gM/gN antibody titers might enhance serum neutralizing capacity among seropositive adults.
KW - congenital cytomegalovirus infection
KW - glycoprotein antibodies
KW - prematurity
KW - seroimmunity
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85133849699&partnerID=8YFLogxK
U2 - 10.3389/fped.2022.846254
DO - 10.3389/fped.2022.846254
M3 - Article
AN - SCOPUS:85133849699
SN - 2296-2360
VL - 10
JO - Frontiers in Pediatrics
JF - Frontiers in Pediatrics
M1 - 846254
ER -