Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II

Julian Mustroph; Maria J. Baier; Steffen Pabel; Thea Stehle; Maximilian Trum; Zdenek Provaznik; Peter J. Mohler; Hassan Musa; Thomas J. Hund; Samuel Sossalla; Lars S. Maier; Stefan Wagner

doi:10.1161/CIRCULATIONAHA.122.057364

Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II

Julian Mustroph, Maria J. Baier, Steffen Pabel, Thea Stehle, Maximilian Trum, Zdenek Provaznik, Peter J. Mohler, Hassan Musa, Thomas J. Hund, Samuel Sossalla, Lars S. Maier, Stefan Wagner

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Original language	English
Pages (from-to)	1259-1261
Number of pages	3
Journal	Circulation
Volume	146
Issue number	16
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.122.057364
State	Published - Oct 18 2022

Keywords

CaMKII
SGLT2 inhibitors
heart failure

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10.1161/CIRCULATIONAHA.122.057364

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title = "Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II",

keywords = "CaMKII, SGLT2 inhibitors, heart failure",

author = "Julian Mustroph and Baier, {Maria J.} and Steffen Pabel and Thea Stehle and Maximilian Trum and Zdenek Provaznik and Mohler, {Peter J.} and Hassan Musa and Hund, {Thomas J.} and Samuel Sossalla and Maier, {Lars S.} and Stefan Wagner",

note = "Funding Information: J.M. is funded by the German Cardiac Society Clinician Scientist program and by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant MU 4555/2-1. L.S.M. is funded by DFG grant MA1982/5-1. S.W. and L.S.M. are funded by SFB 1350 TPA6 and the University of Regensburg ReForM C program. S.W. is funded by DFG grants WA 2539/4-1, 5-1, 7-1, and 8-1. M.J.B. is supported by German Heart Foundation/German Foundation of Heart Research grant F/50/20. S.P., T.S., and M.T. are funded by the Else-Kr{\"o}ner-Fresenius Stiftung (EKFS, 2019_A84). S.S. is funded by DFG (SO 1223/4-1) and EKFS (2017_A137). P.J.M. is funded by National Institute of Health grant R35 HL135754 and by Leducq Foundation. T.J.H. is funded by National Institute of Health grants R01 HL156652 and R01 HL135096. ",

year = "2022",

month = oct,

day = "18",

doi = "10.1161/CIRCULATIONAHA.122.057364",

language = "English",

volume = "146",

pages = "1259--1261",

journal = "Circulation",

issn = "0009-7322",

number = "16",

}

TY - JOUR

T1 - Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II

AU - Mustroph, Julian

AU - Baier, Maria J.

AU - Pabel, Steffen

AU - Stehle, Thea

AU - Trum, Maximilian

AU - Provaznik, Zdenek

AU - Mohler, Peter J.

AU - Musa, Hassan

AU - Hund, Thomas J.

AU - Sossalla, Samuel

AU - Maier, Lars S.

AU - Wagner, Stefan

N1 - Funding Information: J.M. is funded by the German Cardiac Society Clinician Scientist program and by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) grant MU 4555/2-1. L.S.M. is funded by DFG grant MA1982/5-1. S.W. and L.S.M. are funded by SFB 1350 TPA6 and the University of Regensburg ReForM C program. S.W. is funded by DFG grants WA 2539/4-1, 5-1, 7-1, and 8-1. M.J.B. is supported by German Heart Foundation/German Foundation of Heart Research grant F/50/20. S.P., T.S., and M.T. are funded by the Else-Kröner-Fresenius Stiftung (EKFS, 2019_A84). S.S. is funded by DFG (SO 1223/4-1) and EKFS (2017_A137). P.J.M. is funded by National Institute of Health grant R35 HL135754 and by Leducq Foundation. T.J.H. is funded by National Institute of Health grants R01 HL156652 and R01 HL135096.

PY - 2022/10/18

Y1 - 2022/10/18

KW - CaMKII

KW - SGLT2 inhibitors

KW - heart failure

UR - http://www.scopus.com/inward/record.url?scp=85140271219&partnerID=8YFLogxK

U2 - 10.1161/CIRCULATIONAHA.122.057364

DO - 10.1161/CIRCULATIONAHA.122.057364

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AN - SCOPUS:85140271219

SN - 0009-7322

VL - 146

SP - 1259

EP - 1261

JO - Circulation

JF - Circulation

IS - 16

ER -

Empagliflozin Inhibits Cardiac Late Sodium Current by Ca/Calmodulin-Dependent Kinase II

Keywords

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