Illuminating the mechanism of IL-6-mediated immunotherapy resistance

Anna E. Vilgelm

doi:10.1016/j.xcrm.2022.100901

Illuminating the mechanism of IL-6-mediated immunotherapy resistance

Anna E. Vilgelm

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.

Original language	English
Article number	100901
Journal	Cell Reports Medicine
Volume	4
Issue number	1
DOIs	https://doi.org/10.1016/j.xcrm.2022.100901
State	Published - Jan 17 2023

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10.1016/j.xcrm.2022.100901

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title = "Illuminating the mechanism of IL-6-mediated immunotherapy resistance",

abstract = "Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.",

author = "Vilgelm, {Anna E.}",

note = "Funding Information: The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2022 The Author(s)",

year = "2023",

month = jan,

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AU - Vilgelm, Anna E.

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AB - Huseni et al. report that IL-6-STAT3 signaling negatively impacts the anti-tumor function of cytotoxic T cells. Targeting IL-6 signaling may enhance tumor responses to immune checkpoint blockade therapy.

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DO - 10.1016/j.xcrm.2022.100901

M3 - Comment/debate

C2 - 36652910

AN - SCOPUS:85146327626

SN - 2666-3791

VL - 4

JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 1

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Illuminating the mechanism of IL-6-mediated immunotherapy resistance

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