TY - JOUR
T1 - Sleep and circadian rhythms
T2 - pillars of health—a Keystone Symposia report
AU - Cable, Jennifer
AU - Schernhammer, Eva
AU - Hanlon, Erin C.
AU - Vetter, Céline
AU - Cedernaes, Jonathan
AU - Makarem, Nour
AU - Dashti, Hassan S.
AU - Shechter, Ari
AU - Depner, Christopher
AU - Ingiosi, Ashley
AU - Blume, Christine
AU - Tan, Xiao
AU - Gottlieb, Elie
AU - Benedict, Christian
AU - Van Cauter, Eve
AU - St-Onge, Marie Pierre
N1 - Funding Information:
C. Benedict’s work is funded by the Novo Nordisk Foundation and the Swedish Brain Foundation. C.V.’s work is funded by the NIH, the University of Colorado Boulder, and the Colorado Clinical and Translational Sciences Initiative. N.M.’s work is funded by the NIH and the American Heart Association.
Publisher Copyright:
© 2021 New York Academy of Sciences.
PY - 2021/12
Y1 - 2021/12
N2 - The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as in peripheral molecular clocks located in organs throughout the body. This system plays a major role in the temporal organization of biological and physiological processes, such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions, which all manifest consistent diurnal patterns. Many facets of modern life, such as work schedules, travel, and social activities, can lead to sleep/wake and eating schedules that are misaligned relative to the biological clock. This misalignment can disrupt and impair physiological and psychological parameters that may ultimately put people at higher risk for chronic diseases like cancer, cardiovascular disease, and other metabolic disorders. Understanding the mechanisms that regulate sleep circadian rhythms may ultimately lead to insights on behavioral interventions that can lower the risk of these diseases. On February 25, 2021, experts in sleep, circadian rhythms, and chronobiology met virtually for the Keystone eSymposium “Sleep & Circadian Rhythms: Pillars of Health” to discuss the latest research for understanding the bidirectional relationships between sleep, circadian rhythms, and health and disease.
AB - The human circadian system consists of the master clock in the suprachiasmatic nuclei of the hypothalamus as well as in peripheral molecular clocks located in organs throughout the body. This system plays a major role in the temporal organization of biological and physiological processes, such as body temperature, blood pressure, hormone secretion, gene expression, and immune functions, which all manifest consistent diurnal patterns. Many facets of modern life, such as work schedules, travel, and social activities, can lead to sleep/wake and eating schedules that are misaligned relative to the biological clock. This misalignment can disrupt and impair physiological and psychological parameters that may ultimately put people at higher risk for chronic diseases like cancer, cardiovascular disease, and other metabolic disorders. Understanding the mechanisms that regulate sleep circadian rhythms may ultimately lead to insights on behavioral interventions that can lower the risk of these diseases. On February 25, 2021, experts in sleep, circadian rhythms, and chronobiology met virtually for the Keystone eSymposium “Sleep & Circadian Rhythms: Pillars of Health” to discuss the latest research for understanding the bidirectional relationships between sleep, circadian rhythms, and health and disease.
UR - http://www.scopus.com/inward/record.url?scp=85121693136&partnerID=8YFLogxK
U2 - 10.1111/nyas.14661
DO - 10.1111/nyas.14661
M3 - Article
C2 - 34341993
AN - SCOPUS:85121693136
SN - 0077-8923
VL - 1506
SP - 18
EP - 34
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
IS - 1
ER -