Social distancing and extremely preterm births in the initial COVID-19 pandemic period

Vivek V. Shukla; Benjamin A. Carper; Namasivayam Ambalavanan; Matthew A. Rysavy; Edward F. Bell; Abhik Das; Ravi M. Patel; Carl T. D’Angio; Kristi L. Watterberg; C. Michael Cotten; Stephanie L. Merhar; Myra H. Wyckoff; Pablo J. Sánchez; Neha Kumbhat; Waldemar A. Carlo; Richard A. Polin; Abbot R. Laptook; Martin Keszler; Angelita M. Hensman; Elisa Vieira; Lucille St Pierre; Anna Maria Hibbs; Michele C. Walsh; Nancy S. Newman; Sarah Smucney; Arlene Zadell; Brenda B. Poindexter; Kurt Schibler; Cathy Grisby; Kristin Kirker; Sandra Wuertz; Juanita Dudley; Traci Beiersdorfer; Julia Thompson; Ronald N. Goldberg; Joanne Finkle; Kimberley A. Fisher; Matthew M. Laughon; Gennie Bose; Cindy Clark; Stephen D. Kicklighter; Donna White; David P. Carlton; Yvonne Loggins; Judith Laursen; Colleen Mackie; Diane I. Bottcher; Andrew A. Bremer; Rosemary D. Higgins; Stephanie Wilson Archer; Jon E. Tyson; Amir M. Khan; Barbara J. Stoll; Gabriela Dominguez; Elizabeth Eason; Donna J. Hall; Apoorva Mahatme; Karen Martin; Ilse Reyna; Emily K. Stephens; Jaleesa Wade; Michelle White; Leif D. Nelin; Sudarshan R. Jadcherla; Jonathan L. Slaughter; Patricia Luzader; Jacqueline McCool; Kyrstin Warnimont; Jessica Purnell; Kristi Small; Melanie Stein; Rox Ann Sullivan; Laura Marzac; Hallie Baugher; Eli Zettler; Bethany Miller; Demi R. Beckford; Brittany DeSantis; Rachel Reedy; Marie G. Gantz; Carla M. Bann; Kristin M. Zaterka-Baxter; Jenna Gabrio; David Leblond; Jeanette O’Donnell Auman; Krisa P. Van Meurs; David K. Stevenson; Valerie Y. Chock; M. Bethany Ball; Barbara P. Recine; Elizabeth N. Reichert; Monica V. Collins; Shirley S. Cosby; Tarah T. Colaizy; Heidi M. Harmon; Michelle L. Baack; Laurie A. Hogden; Karen J. Johnson; Mendi L. Schmelzel; Jacky R. Walker; Claire A. Goeke; Sarah E. Faruqui; Brenda J. Coulter; Bailey M. Schrimper; Syndney S. Jellison; Chelsey Elenkiwich; Megan M. Henning; Megan Broadbent; Sarah Van Muyden; Janell Fuller; Robin K. Ohls; Sandra Sundquist Beauman; Conra Backstrom Lacy; Mary Hanson; Elizabeth Kuan; Sara B. DeMauro; Eric C. Eichenwald; Soraya Abbasi; Christine Catts; Aasma S. Chaudhary; Megan A. Dhawan; Sarvin Ghavam; Toni Mancini; Karen M. Puopolo; Jonathan Snyder; Ronnie Guillet; Anne Marie Reynolds; Satyan Lakshminrusimha; Michael G. Sacilowski; Mary Rowan; Rosemary Jensen; Rachel Jones; Alison Kent; Diane Prinzing; Ann Marie Scorsone; Kyle Binion; Stephanie Guilford; Constance Orme; Premini Sabaratnam; Daisy Rochez; Emily Li; Jennifer Donato; Luc P. Brion; Joanne Duran; Frances Eubanks; Michelle Harrod; Pollieanna Sepulvida; Diana M. Vasil; Bradley A. Yoder; Mariana Baserga; Stephen D. Minton; Mark J. Sheffield; Carrie A. Rau; Susan Christensen; Kathleen Coleman; Jennifer O. Elmont; Barbara L. Francom; Jamie Jordan; Manndi C. Loertscher; Trisha Marchant; Earl Maxson; Kandace McGrath; Hena G. Mickelsen; D. Melody Parry; Katherine Tice; Kimberlee Weaver-Lewis; Kathryn D. Woodbury

doi:10.1038/s41372-024-01898-3

Social distancing and extremely preterm births in the initial COVID-19 pandemic period

Vivek V. Shukla, Benjamin A. Carper, Namasivayam Ambalavanan, Matthew A. Rysavy, Edward F. Bell, Abhik Das, Ravi M. Patel, Carl T. D’Angio, Kristi L. Watterberg, C. Michael Cotten, Stephanie L. Merhar, Myra H. Wyckoff, Pablo J. Sánchez, Neha Kumbhat, Waldemar A. Carlo, Richard A. Polin, Abbot R. Laptook, Martin Keszler, Angelita M. Hensman, Elisa VieiraLucille St Pierre, Anna Maria Hibbs, Michele C. Walsh, Nancy S. Newman, Sarah Smucney, Arlene Zadell, Brenda B. Poindexter, Kurt Schibler, Cathy Grisby, Kristin Kirker, Sandra Wuertz, Juanita Dudley, Traci Beiersdorfer, Julia Thompson, Ronald N. Goldberg, Joanne Finkle, Kimberley A. Fisher, Matthew M. Laughon, Gennie Bose, Cindy Clark, Stephen D. Kicklighter, Donna White, David P. Carlton, Yvonne Loggins, Judith Laursen, Colleen Mackie, Diane I. Bottcher, Andrew A. Bremer, Rosemary D. Higgins, Stephanie Wilson Archer, Jon E. Tyson, Amir M. Khan, Barbara J. Stoll, Gabriela Dominguez, Elizabeth Eason, Donna J. Hall, Apoorva Mahatme, Karen Martin, Ilse Reyna, Emily K. Stephens, Jaleesa Wade, Michelle White, Leif D. Nelin, Sudarshan R. Jadcherla, Jonathan L. Slaughter, Patricia Luzader, Jacqueline McCool, Kyrstin Warnimont, Jessica Purnell, Kristi Small, Melanie Stein, Rox Ann Sullivan, Laura Marzac, Hallie Baugher, Eli Zettler, Bethany Miller, Demi R. Beckford, Brittany DeSantis, Rachel Reedy, Marie G. Gantz, Carla M. Bann, Kristin M. Zaterka-Baxter, Jenna Gabrio, David Leblond, Jeanette O’Donnell Auman, Krisa P. Van Meurs, David K. Stevenson, Valerie Y. Chock, M. Bethany Ball, Barbara P. Recine, Elizabeth N. Reichert, Monica V. Collins, Shirley S. Cosby, Tarah T. Colaizy, Heidi M. Harmon, Michelle L. Baack, Laurie A. Hogden, Karen J. Johnson, Mendi L. Schmelzel, Jacky R. Walker, Claire A. Goeke, Sarah E. Faruqui, Brenda J. Coulter, Bailey M. Schrimper, Syndney S. Jellison, Chelsey Elenkiwich, Megan M. Henning, Megan Broadbent, Sarah Van Muyden, Janell Fuller, Robin K. Ohls, Sandra Sundquist Beauman, Conra Backstrom Lacy, Mary Hanson, Elizabeth Kuan, Sara B. DeMauro, Eric C. Eichenwald, Soraya Abbasi, Christine Catts, Aasma S. Chaudhary, Megan A. Dhawan, Sarvin Ghavam, Toni Mancini, Karen M. Puopolo, Jonathan Snyder, Ronnie Guillet, Anne Marie Reynolds, Satyan Lakshminrusimha, Michael G. Sacilowski, Mary Rowan, Rosemary Jensen, Rachel Jones, Alison Kent, Diane Prinzing, Ann Marie Scorsone, Kyle Binion, Stephanie Guilford, Constance Orme, Premini Sabaratnam, Daisy Rochez, Emily Li, Jennifer Donato, Luc P. Brion, Joanne Duran, Frances Eubanks, Michelle Harrod, Pollieanna Sepulvida, Diana M. Vasil, Bradley A. Yoder, Mariana Baserga, Stephen D. Minton, Mark J. Sheffield, Carrie A. Rau, Susan Christensen, Kathleen Coleman, Jennifer O. Elmont, Barbara L. Francom, Jamie Jordan, Manndi C. Loertscher, Trisha Marchant, Earl Maxson, Kandace McGrath, Hena G. Mickelsen, D. Melody Parry, Katherine Tice, Kimberlee Weaver-Lewis, Kathryn D. Woodbury

Research output: Contribution to journal › Article › peer-review

Abstract

Hypothesis: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. Study design: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (22^0/7–28^6/7 weeks) and extremely preterm intrapartum stillbirths (EPIS) rates during the pandemic period (March-July, weeks 9–30 of 2020) with the reference period (same weeks in 2018 and 2019), correlating with state-specific social distancing index (SDI). Results: EPLB and EPIS percentages did not significantly decrease (1.58–1.45%, p = 0.07, and 0.08–0.06%, p = 0.14, respectively). SDI was not significantly correlated with percent change of EPLB (CC = 0.29, 95% CI = −0.12, 0.71) or EPIS (CC = −0.23, 95% CI = −0.65, 0.18). Percent change in mean gestational age was positively correlated with SDI (CC = 0.49, 95% CI = 0.07, 0.91). Conclusions: Increased social distancing was not associated with change in incidence of EPLB but was associated with a higher gestational age of extremely preterm births. ClinicalTrials.gov ID: Generic Database: NCT00063063.

Original language	English
Journal	Journal of Perinatology
DOIs	https://doi.org/10.1038/s41372-024-01898-3
State	Accepted/In press - 2024

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10.1038/s41372-024-01898-3

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Shukla, V. V., Carper, B. A., Ambalavanan, N., Rysavy, M. A., Bell, E. F., Das, A., Patel, R. M., D’Angio, C. T., Watterberg, K. L., Cotten, C. M., Merhar, S. L., Wyckoff, M. H., Sánchez, P. J., Kumbhat, N., Carlo, W. A., Polin, R. A., Laptook, A. R., Keszler, M., Hensman, A. M., ... Woodbury, K. D. (Accepted/In press). Social distancing and extremely preterm births in the initial COVID-19 pandemic period. Journal of Perinatology. https://doi.org/10.1038/s41372-024-01898-3

@article{c79aa5f807684c998e7469ef10dcb6c7,

title = "Social distancing and extremely preterm births in the initial COVID-19 pandemic period",

abstract = "Hypothesis: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. Study design: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (220/7–286/7 weeks) and extremely preterm intrapartum stillbirths (EPIS) rates during the pandemic period (March-July, weeks 9–30 of 2020) with the reference period (same weeks in 2018 and 2019), correlating with state-specific social distancing index (SDI). Results: EPLB and EPIS percentages did not significantly decrease (1.58–1.45%, p = 0.07, and 0.08–0.06%, p = 0.14, respectively). SDI was not significantly correlated with percent change of EPLB (CC = 0.29, 95% CI = −0.12, 0.71) or EPIS (CC = −0.23, 95% CI = −0.65, 0.18). Percent change in mean gestational age was positively correlated with SDI (CC = 0.49, 95% CI = 0.07, 0.91). Conclusions: Increased social distancing was not associated with change in incidence of EPLB but was associated with a higher gestational age of extremely preterm births. ClinicalTrials.gov ID: Generic Database: NCT00063063.",

author = "Shukla, {Vivek V.} and Carper, {Benjamin A.} and Namasivayam Ambalavanan and Rysavy, {Matthew A.} and Bell, {Edward F.} and Abhik Das and Patel, {Ravi M.} and D{\textquoteright}Angio, {Carl T.} and Watterberg, {Kristi L.} and Cotten, {C. Michael} and Merhar, {Stephanie L.} and Wyckoff, {Myra H.} and S{\'a}nchez, {Pablo J.} and Neha Kumbhat and Carlo, {Waldemar A.} and Polin, {Richard A.} and Laptook, {Abbot R.} and Martin Keszler and Hensman, {Angelita M.} and Elisa Vieira and Pierre, {Lucille St} and Hibbs, {Anna Maria} and Walsh, {Michele C.} and Newman, {Nancy S.} and Sarah Smucney and Arlene Zadell and Poindexter, {Brenda B.} and Kurt Schibler and Cathy Grisby and Kristin Kirker and Sandra Wuertz and Juanita Dudley and Traci Beiersdorfer and Julia Thompson and Goldberg, {Ronald N.} and Joanne Finkle and Fisher, {Kimberley A.} and Laughon, {Matthew M.} and Gennie Bose and Cindy Clark and Kicklighter, {Stephen D.} and Donna White and Carlton, {David P.} and Yvonne Loggins and Judith Laursen and Colleen Mackie and Bottcher, {Diane I.} and Bremer, {Andrew A.} and Higgins, {Rosemary D.} and Archer, {Stephanie Wilson} and Tyson, {Jon E.} and Khan, {Amir M.} and Stoll, {Barbara J.} and Gabriela Dominguez and Elizabeth Eason and Hall, {Donna J.} and Apoorva Mahatme and Karen Martin and Ilse Reyna and Stephens, {Emily K.} and Jaleesa Wade and Michelle White and Nelin, {Leif D.} and Jadcherla, {Sudarshan R.} and Slaughter, {Jonathan L.} and Patricia Luzader and Jacqueline McCool and Kyrstin Warnimont and Jessica Purnell and Kristi Small and Melanie Stein and Sullivan, {Rox Ann} and Laura Marzac and Hallie Baugher and Eli Zettler and Bethany Miller and Beckford, {Demi R.} and Brittany DeSantis and Rachel Reedy and Gantz, {Marie G.} and Bann, {Carla M.} and Zaterka-Baxter, {Kristin M.} and Jenna Gabrio and David Leblond and {O{\textquoteright}Donnell Auman}, Jeanette and {Van Meurs}, {Krisa P.} and Stevenson, {David K.} and Chock, {Valerie Y.} and Ball, {M. Bethany} and Recine, {Barbara P.} and Reichert, {Elizabeth N.} and Collins, {Monica V.} and Cosby, {Shirley S.} and Colaizy, {Tarah T.} and Harmon, {Heidi M.} and Baack, {Michelle L.} and Hogden, {Laurie A.} and Johnson, {Karen J.} and Schmelzel, {Mendi L.} and Walker, {Jacky R.} and Goeke, {Claire A.} and Faruqui, {Sarah E.} and Coulter, {Brenda J.} and Schrimper, {Bailey M.} and Jellison, {Syndney S.} and Chelsey Elenkiwich and Henning, {Megan M.} and Megan Broadbent and {Van Muyden}, Sarah and Janell Fuller and Ohls, {Robin K.} and Beauman, {Sandra Sundquist} and Lacy, {Conra Backstrom} and Mary Hanson and Elizabeth Kuan and DeMauro, {Sara B.} and Eichenwald, {Eric C.} and Soraya Abbasi and Christine Catts and Chaudhary, {Aasma S.} and Dhawan, {Megan A.} and Sarvin Ghavam and Toni Mancini and Puopolo, {Karen M.} and Jonathan Snyder and Ronnie Guillet and Reynolds, {Anne Marie} and Satyan Lakshminrusimha and Sacilowski, {Michael G.} and Mary Rowan and Rosemary Jensen and Rachel Jones and Alison Kent and Diane Prinzing and Scorsone, {Ann Marie} and Kyle Binion and Stephanie Guilford and Constance Orme and Premini Sabaratnam and Daisy Rochez and Emily Li and Jennifer Donato and Brion, {Luc P.} and Joanne Duran and Frances Eubanks and Michelle Harrod and Pollieanna Sepulvida and Vasil, {Diana M.} and Yoder, {Bradley A.} and Mariana Baserga and Minton, {Stephen D.} and Sheffield, {Mark J.} and Rau, {Carrie A.} and Susan Christensen and Kathleen Coleman and Elmont, {Jennifer O.} and Francom, {Barbara L.} and Jamie Jordan and Loertscher, {Manndi C.} and Trisha Marchant and Earl Maxson and Kandace McGrath and Mickelsen, {Hena G.} and Parry, {D. Melody} and Katherine Tice and Kimberlee Weaver-Lewis and Woodbury, {Kathryn D.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

doi = "10.1038/s41372-024-01898-3",

language = "English",

journal = "Journal of Perinatology",

issn = "0743-8346",

}

Shukla, VV, Carper, BA, Ambalavanan, N, Rysavy, MA, Bell, EF, Das, A, Patel, RM, D’Angio, CT, Watterberg, KL, Cotten, CM, Merhar, SL, Wyckoff, MH, Sánchez, PJ, Kumbhat, N, Carlo, WA, Polin, RA, Laptook, AR, Keszler, M, Hensman, AM, Vieira, E, Pierre, LS, Hibbs, AM, Walsh, MC, Newman, NS, Smucney, S, Zadell, A, Poindexter, BB, Schibler, K, Grisby, C, Kirker, K, Wuertz, S, Dudley, J, Beiersdorfer, T, Thompson, J, Goldberg, RN, Finkle, J, Fisher, KA, Laughon, MM, Bose, G, Clark, C, Kicklighter, SD, White, D, Carlton, DP, Loggins, Y, Laursen, J, Mackie, C, Bottcher, DI, Bremer, AA, Higgins, RD, Archer, SW, Tyson, JE, Khan, AM, Stoll, BJ, Dominguez, G, Eason, E, Hall, DJ, Mahatme, A, Martin, K, Reyna, I, Stephens, EK, Wade, J, White, M, Nelin, LD , Jadcherla, SR , Slaughter, JL, Luzader, P, McCool, J, Warnimont, K, Purnell, J, Small, K, Stein, M, Sullivan, RA, Marzac, L, Baugher, H, Zettler, E, Miller, B, Beckford, DR, DeSantis, B, Reedy, R, Gantz, MG, Bann, CM, Zaterka-Baxter, KM, Gabrio, J, Leblond, D, O’Donnell Auman, J, Van Meurs, KP, Stevenson, DK, Chock, VY, Ball, MB, Recine, BP, Reichert, EN, Collins, MV, Cosby, SS, Colaizy, TT, Harmon, HM, Baack, ML, Hogden, LA, Johnson, KJ, Schmelzel, ML, Walker, JR, Goeke, CA, Faruqui, SE, Coulter, BJ, Schrimper, BM, Jellison, SS, Elenkiwich, C, Henning, MM, Broadbent, M, Van Muyden, S, Fuller, J, Ohls, RK, Beauman, SS, Lacy, CB, Hanson, M, Kuan, E, DeMauro, SB, Eichenwald, EC, Abbasi, S, Catts, C, Chaudhary, AS, Dhawan, MA, Ghavam, S, Mancini, T, Puopolo, KM, Snyder, J, Guillet, R, Reynolds, AM, Lakshminrusimha, S, Sacilowski, MG, Rowan, M, Jensen, R, Jones, R, Kent, A, Prinzing, D, Scorsone, AM, Binion, K, Guilford, S, Orme, C, Sabaratnam, P, Rochez, D, Li, E, Donato, J, Brion, LP, Duran, J, Eubanks, F, Harrod, M, Sepulvida, P, Vasil, DM, Yoder, BA, Baserga, M, Minton, SD, Sheffield, MJ, Rau, CA, Christensen, S, Coleman, K, Elmont, JO, Francom, BL, Jordan, J, Loertscher, MC, Marchant, T, Maxson, E, McGrath, K, Mickelsen, HG, Parry, DM, Tice, K, Weaver-Lewis, K & Woodbury, KD 2024, 'Social distancing and extremely preterm births in the initial COVID-19 pandemic period', Journal of Perinatology. https://doi.org/10.1038/s41372-024-01898-3

TY - JOUR

T1 - Social distancing and extremely preterm births in the initial COVID-19 pandemic period

AU - Shukla, Vivek V.

AU - Carper, Benjamin A.

AU - Ambalavanan, Namasivayam

AU - Rysavy, Matthew A.

AU - Bell, Edward F.

AU - Das, Abhik

AU - Patel, Ravi M.

AU - D’Angio, Carl T.

AU - Watterberg, Kristi L.

AU - Cotten, C. Michael

AU - Merhar, Stephanie L.

AU - Wyckoff, Myra H.

AU - Sánchez, Pablo J.

AU - Kumbhat, Neha

AU - Carlo, Waldemar A.

AU - Polin, Richard A.

AU - Laptook, Abbot R.

AU - Keszler, Martin

AU - Hensman, Angelita M.

AU - Vieira, Elisa

AU - Pierre, Lucille St

AU - Hibbs, Anna Maria

AU - Walsh, Michele C.

AU - Newman, Nancy S.

AU - Smucney, Sarah

AU - Zadell, Arlene

AU - Poindexter, Brenda B.

AU - Schibler, Kurt

AU - Grisby, Cathy

AU - Kirker, Kristin

AU - Wuertz, Sandra

AU - Dudley, Juanita

AU - Beiersdorfer, Traci

AU - Thompson, Julia

AU - Goldberg, Ronald N.

AU - Finkle, Joanne

AU - Fisher, Kimberley A.

AU - Laughon, Matthew M.

AU - Bose, Gennie

AU - Clark, Cindy

AU - Kicklighter, Stephen D.

AU - White, Donna

AU - Carlton, David P.

AU - Loggins, Yvonne

AU - Laursen, Judith

AU - Mackie, Colleen

AU - Bottcher, Diane I.

AU - Bremer, Andrew A.

AU - Higgins, Rosemary D.

AU - Archer, Stephanie Wilson

AU - Tyson, Jon E.

AU - Khan, Amir M.

AU - Stoll, Barbara J.

AU - Dominguez, Gabriela

AU - Eason, Elizabeth

AU - Hall, Donna J.

AU - Mahatme, Apoorva

AU - Martin, Karen

AU - Reyna, Ilse

AU - Stephens, Emily K.

AU - Wade, Jaleesa

AU - White, Michelle

AU - Nelin, Leif D.

AU - Jadcherla, Sudarshan R.

AU - Slaughter, Jonathan L.

AU - Luzader, Patricia

AU - McCool, Jacqueline

AU - Warnimont, Kyrstin

AU - Purnell, Jessica

AU - Small, Kristi

AU - Stein, Melanie

AU - Sullivan, Rox Ann

AU - Marzac, Laura

AU - Baugher, Hallie

AU - Zettler, Eli

AU - Miller, Bethany

AU - Beckford, Demi R.

AU - DeSantis, Brittany

AU - Reedy, Rachel

AU - Gantz, Marie G.

AU - Bann, Carla M.

AU - Zaterka-Baxter, Kristin M.

AU - Gabrio, Jenna

AU - Leblond, David

AU - O’Donnell Auman, Jeanette

AU - Van Meurs, Krisa P.

AU - Stevenson, David K.

AU - Chock, Valerie Y.

AU - Ball, M. Bethany

AU - Recine, Barbara P.

AU - Reichert, Elizabeth N.

AU - Collins, Monica V.

AU - Cosby, Shirley S.

AU - Colaizy, Tarah T.

AU - Harmon, Heidi M.

AU - Baack, Michelle L.

AU - Hogden, Laurie A.

AU - Johnson, Karen J.

AU - Schmelzel, Mendi L.

AU - Walker, Jacky R.

AU - Goeke, Claire A.

AU - Faruqui, Sarah E.

AU - Coulter, Brenda J.

AU - Schrimper, Bailey M.

AU - Jellison, Syndney S.

AU - Elenkiwich, Chelsey

AU - Henning, Megan M.

AU - Broadbent, Megan

AU - Van Muyden, Sarah

AU - Fuller, Janell

AU - Ohls, Robin K.

AU - Beauman, Sandra Sundquist

AU - Lacy, Conra Backstrom

AU - Hanson, Mary

AU - Kuan, Elizabeth

AU - DeMauro, Sara B.

AU - Eichenwald, Eric C.

AU - Abbasi, Soraya

AU - Catts, Christine

AU - Chaudhary, Aasma S.

AU - Dhawan, Megan A.

AU - Ghavam, Sarvin

AU - Mancini, Toni

AU - Puopolo, Karen M.

AU - Snyder, Jonathan

AU - Guillet, Ronnie

AU - Reynolds, Anne Marie

AU - Lakshminrusimha, Satyan

AU - Sacilowski, Michael G.

AU - Rowan, Mary

AU - Jensen, Rosemary

AU - Jones, Rachel

AU - Kent, Alison

AU - Prinzing, Diane

AU - Scorsone, Ann Marie

AU - Binion, Kyle

AU - Guilford, Stephanie

AU - Orme, Constance

AU - Sabaratnam, Premini

AU - Rochez, Daisy

AU - Li, Emily

AU - Donato, Jennifer

AU - Brion, Luc P.

AU - Duran, Joanne

AU - Eubanks, Frances

AU - Harrod, Michelle

AU - Sepulvida, Pollieanna

AU - Vasil, Diana M.

AU - Yoder, Bradley A.

AU - Baserga, Mariana

AU - Minton, Stephen D.

AU - Sheffield, Mark J.

AU - Rau, Carrie A.

AU - Christensen, Susan

AU - Coleman, Kathleen

AU - Elmont, Jennifer O.

AU - Francom, Barbara L.

AU - Jordan, Jamie

AU - Loertscher, Manndi C.

AU - Marchant, Trisha

AU - Maxson, Earl

AU - McGrath, Kandace

AU - Mickelsen, Hena G.

AU - Parry, D. Melody

AU - Tice, Katherine

AU - Weaver-Lewis, Kimberlee

AU - Woodbury, Kathryn D.

PY - 2024

Y1 - 2024

N2 - Hypothesis: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. Study design: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (220/7–286/7 weeks) and extremely preterm intrapartum stillbirths (EPIS) rates during the pandemic period (March-July, weeks 9–30 of 2020) with the reference period (same weeks in 2018 and 2019), correlating with state-specific social distancing index (SDI). Results: EPLB and EPIS percentages did not significantly decrease (1.58–1.45%, p = 0.07, and 0.08–0.06%, p = 0.14, respectively). SDI was not significantly correlated with percent change of EPLB (CC = 0.29, 95% CI = −0.12, 0.71) or EPIS (CC = −0.23, 95% CI = −0.65, 0.18). Percent change in mean gestational age was positively correlated with SDI (CC = 0.49, 95% CI = 0.07, 0.91). Conclusions: Increased social distancing was not associated with change in incidence of EPLB but was associated with a higher gestational age of extremely preterm births. ClinicalTrials.gov ID: Generic Database: NCT00063063.

AB - Hypothesis: Increased social distancing was associated with a lower incidence of extremely preterm live births (EPLB) during the initial COVID-19 pandemic period. Study design: Prospective study at the NICHD Neonatal Research Network sites comparing EPLB (220/7–286/7 weeks) and extremely preterm intrapartum stillbirths (EPIS) rates during the pandemic period (March-July, weeks 9–30 of 2020) with the reference period (same weeks in 2018 and 2019), correlating with state-specific social distancing index (SDI). Results: EPLB and EPIS percentages did not significantly decrease (1.58–1.45%, p = 0.07, and 0.08–0.06%, p = 0.14, respectively). SDI was not significantly correlated with percent change of EPLB (CC = 0.29, 95% CI = −0.12, 0.71) or EPIS (CC = −0.23, 95% CI = −0.65, 0.18). Percent change in mean gestational age was positively correlated with SDI (CC = 0.49, 95% CI = 0.07, 0.91). Conclusions: Increased social distancing was not associated with change in incidence of EPLB but was associated with a higher gestational age of extremely preterm births. ClinicalTrials.gov ID: Generic Database: NCT00063063.

UR - http://www.scopus.com/inward/record.url?scp=85185665019&partnerID=8YFLogxK

U2 - 10.1038/s41372-024-01898-3

DO - 10.1038/s41372-024-01898-3

M3 - Article

AN - SCOPUS:85185665019

SN - 0743-8346

JO - Journal of Perinatology

JF - Journal of Perinatology

ER -

Social distancing and extremely preterm births in the initial COVID-19 pandemic period

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