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Dive into the research topics where Hazem Ghoneim is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
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Projects
- 1 Active
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Enhancing the Effectiveness of Immunotherapies by T Cell Epigenetic Reprogramming
Ghoneim, H. (PI)
National Institute of Allergy and Infectious Diseases
06/5/23 → 05/31/25
Project: Research
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The NAE1-mediated neddylation operates as an essential post-translational modification checkpoint for effector CD8+ T cells
Jin, J., Zhang, R., Li, J., Gao, F., Liao, Z., Yu, Y., Wang, Y., Bucci, D., Xiao, M., Ma, R., Ma, Q., Gao, S., Lio, J., Novais, F., Huang, S. C. C., Zhu, J., Ghoneim, H., Wen, H., Li, Z. & Sun, N. & 1 others, , Mar 11 2025, In: Proceedings of the National Academy of Sciences of the United States of America. 122, 10, e2424061122.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer’s disease
Daily, K. P., Badr, A., Eltobgy, M., Estfanous, S., Whitham, O., Tan, M. H., Carafice, C., Krause, K., McNamara, A., Hamilton, K., Houle, S., Gupta, S., Gupta, G. A., Madhu, S., Fitzgerald, J., Saadey, A. A., Laster, B., Yan, P., Webb, A. & Zhang, X. & 4 others, , Feb 8 2024, In: Alzheimer's Research and Therapy. 16, 1, p. 29 29.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Microglia-targeted inhibition of miR-17 via mannose-coated lipid nanoparticles improves pathology and behavior in a mouse model of Alzheimer's disease
Badr, A., Daily, K. P., Eltobgy, M., Estfanous, S., Tan, M. H., Chun-Tien Kuo, J., Whitham, O., Carafice, C., Gupta, G., Amer, H. M., Shamseldin, M. M., Yousif, A., Deems, N. P., Fitzgerald, J., Yan, P., Webb, A., Zhang, X., Pietrzak, M., Ghoneim, H. E. & Dubey, P. & 4 others, , Jul 2024, In: Brain, Behavior, and Immunity. 119, p. 919-944 26 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Aiolos represses CD4+ T cell cytotoxic programming via reciprocal regulation of TFH transcription factors and IL-2 sensitivity
Read, K. A., Jones, D. M., Pokhrel, S., Hales, E. D. S., Varkey, A., Tuazon, J. A., Eisele, C. D., Abdouni, O., Saadey, A., Leonard, M. R., Warren, R. T., Powell, M. D., Boss, J. M., Hemann, E. A., Yount, J. S., Xin, G., Ghoneim, H. E., Lio, C. W. J., Freud, A. G. & Collins, P. L. & 1 others, , Dec 2023, In: Nature Communications. 14, 1, 1652.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Functional T cells are capable of supernumerary cell division and longevity
Soerens, A. G., Künzli, M., Quarnstrom, C. F., Scott, M. C., Swanson, L., Locquiao, J., Ghoneim, H. E., Zehn, D., Youngblood, B., Vezys, V. & Masopust, D., Feb 23 2023, In: Nature. 614, 7949, p. 762-766 5 p.Research output: Contribution to journal › Article › peer-review
97 Scopus citations